Interactor 1: HES1 (Q14469)
Transcription factor HES-1 (Class B basic helix-loop-helix protein 39) (bHLHb39) (Hairy and enhancer of split 1) (Hairy homolog) (Hairy-like protein) (hHL)
Gene: HES1

Interactor 2: HES1 (Q14469)
Transcription factor HES-1 (Class B basic helix-loop-helix protein 39) (bHLHb39) (Hairy and enhancer of split 1) (Hairy homolog) (Hairy-like protein) (hHL)
Gene: HES1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.54 1.00 0.737

The method score is based on:

Property Details
Experiments 19321451, 35640677
Identification Methods affinity chromatography technology, x-ray crystallography
Interaction Type physical association, association

The annotation score is based on:

Property Details
Interacting Pfam domains Hairy_orange~Hairy_orange, HLH~HLH
Common GO terms GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000785 - chromatin
GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001222 - transcription corepressor binding
GO:0001227 - DNA-binding transcription repressor activity, RNA polymerase II-specific
and 109 others

more...

Homologous interactions 17

Homologous interactions

Color coding for hit scores

1 280
Hs

1 280
+ Hs
+ Hs
+ Hs
+ Gg
+ Mm
+ Gg
+ Hs
+ Dr
+ Hs
+ Dm
+ Dm
+ Dm
+ Dm
+ Mm
+ Dm
+ Dr
+ Dr

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Last updated: 15 Jul 2024