HitPredict

Interactor 1: HES1 (Q14469)
Transcription factor HES-1 (Class B basic helix-loop-helix protein 39) (bHLHb39) (Hairy and enhancer of split 1) (Hairy homolog) (Hairy-like protein) (hHL)
Gene: HES1

Interactor 2: HES6 (Q96HZ4)
Transcription cofactor HES-6 (C-HAIRY1) (Class B basic helix-loop-helix protein 41) (bHLHb41) (Hairy and enhancer of split 6)
Gene: HES6

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.62 1.00 0.789

The method score is based on:

Property Details
Experiments 33961781, 17868320
Identification Methods affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type physical association, association

The annotation score is based on:

Property Details
Interacting Pfam domains Hairy_orange~Hairy_orange, HLH~HLH
Common GO terms GO:0000785 - chromatin
GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001227 - DNA-binding transcription repressor activity, RNA polymerase II-specific
GO:0005634 - nucleus
GO:0006357 - regulation of transcription by RNA polymerase II
and 6 others

more...
Homologous interactions 17

Homologous interactions

Color coding for hit scores

1 280
Hs

1 224
+ Mm
+ Hs
+ Hs
+ Hs
+ Dr
+ Gg
+ Gg
+ Hs
+ Hs
+ Dm
+ Dm
+ Mm
+ Dm
+ Dm
+ Dm
+ Dm
+ Dr

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Last updated: 15 Jul 2024