HitPredict

Interactor 1: NF2L1 (Q14494)
Endoplasmic reticulum membrane sensor NFE2L1 (Locus control region-factor 1) (LCR-F1) (Nuclear factor erythroid 2-related factor 1) (NF-E2-related factor 1) (NFE2-related factor 1) (Nuclear factor, erythroid derived 2, like 1) (Protein NRF1, p120 form) (Transcription factor 11) (TCF-11) [Cleaved into: Transcription factor NRF1 (Protein NRF1, p110 form)]
Gene: NFE2L1

Interactor 2: FBW1B (Q9UKB1)
F-box/WD repeat-containing protein 11 (F-box and WD repeats protein beta-TrCP2) (F-box/WD repeat-containing protein 1B) (Homologous to Slimb protein) (HOS)
Gene: FBXW11

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	25515538
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005829 - cytosol
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 772 Hs			1 542
+	Hs
		1054305 NF2L1_HUMAN (1-772): 0: 903: 100.00		FBW1A_HUMAN (26-542): 3.86e-155: 458: 84.59
+	Hs
		1054294 NF2L1_HUMAN (1-772): 0: 903: 100.00		FBXW7_HUMAN (18-424): 1.12e-72: 246: 20.29
+	Hs
		1081259 NF2L2_HUMAN (162-762): 6.41e-153: 461: 32.55		FBW1B_HUMAN (1-542): 9.69e-174: 503: 100.00
+	Mm
		1112907 NF2L2_MOUSE (162-762): 2.1e-162: 484: 35.19		FBW1A_MOUSE (36-542): 4.82e-154: 455: 85.27
+	Hs
		1081265 NF2L2_HUMAN (162-762): 6.41e-153: 461: 32.55		FBW1A_HUMAN (26-542): 3.86e-155: 458: 84.59
+	Hs
		1083925 NFE2_HUMAN (289-759): 3.57e-65: 223: 30.36		FBW1A_HUMAN (26-542): 3.86e-155: 458: 84.59
+	Hs
		1147425 CR3L3_HUMAN (422-729): 8.76e-48: 177: 17.83		FBW1B_HUMAN (1-542): 9.69e-174: 503: 100.00
+	Hs
		1147427 CR3L3_HUMAN (422-729): 8.76e-48: 177: 17.83		FBW1A_HUMAN (26-542): 3.86e-155: 458: 84.59
+	Hs
		1281509 NF2L3_HUMAN (208-770): 9.15e-124: 388: 34.76		FBXW7_HUMAN (18-424): 1.12e-72: 246: 20.29
+	Hs
		402320 JUN_HUMAN (390-729): 1.67e-53: 190: 14.71		FBXW7_HUMAN (18-424): 1.12e-72: 246: 20.29
+	Hs
		196941 JUN_HUMAN (390-729): 1.67e-53: 190: 14.71		PRP4_HUMAN (320-536): 4.83e-42: 159: 22.13
+	Dm
		576069 JRA_DROME (451-722): 2.72e-38: 146: 17.75		EBI_DROME (274-517): 7.96e-52: 189: 21.32
+	Mm
		903658 NFE2_MOUSE (289-759): 2.61e-73: 245: 31.64		WDR5_MOUSE (80-265): 5.44e-16: 81.1: 11.92
+	Hs
		401905 JUN_HUMAN (390-729): 1.67e-53: 190: 14.71		TBL3_HUMAN (237-531): 4.06e-24: 108: 24.46
+	Hs
		197114 MAFB_HUMAN (486-738): 2.78e-35: 138: 12.16		PRP4_HUMAN (320-536): 4.83e-42: 159: 22.13
+	Mm
		873226 MAFB_MOUSE (618-738): 7.18e-36: 140: 22.31		TAF5_MOUSE (329-539): 7.15e-36: 144: 20.18
+	Hs
		401754 JUN_HUMAN (390-729): 1.67e-53: 190: 14.71		WDR5_HUMAN (80-265): 5.44e-16: 81.1: 11.92
+	Hs
		402538 JUN_HUMAN (390-729): 1.67e-53: 190: 14.71		NLE1_HUMAN (125-224): 6.61e-09: 60.3: 6.00
+	Mm
		903672 MAFA_MOUSE (625-747): 1.32e-30: 125: 24.39		WDR5_MOUSE (80-265): 5.44e-16: 81.1: 11.92