HitPredict

Interactor 1: NF2L1 (Q14494)
Endoplasmic reticulum membrane sensor NFE2L1 (Locus control region-factor 1) (LCR-F1) (Nuclear factor erythroid 2-related factor 1) (NF-E2-related factor 1) (NFE2-related factor 1) (Nuclear factor, erythroid derived 2, like 1) (Protein NRF1, p120 form) (Transcription factor 11) (TCF-11) [Cleaved into: Transcription factor NRF1 (Protein NRF1, p110 form)]
Gene: NFE2L1

Interactor 2: FBW1A (Q9Y297)
F-box/WD repeat-containing protein 1A (E3RSIkappaB) (Epididymis tissue protein Li 2a) (F-box and WD repeats protein beta-TrCP) (pIkappaBalpha-E3 receptor subunit)
Gene: BTRC

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.60	0.60	0.601

Property	Details
Experiments	25900982, 29941490
Identification Methods	affinity chromatography technology, proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005654 - nucleoplasm GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 772 Hs			1 605
+	Hs
		1054303 NF2L1_HUMAN (1-772): 0: 903: 100.00		FBW1B_HUMAN (96-605): 1.89e-143: 428: 85.69
+	Hs
		1054294 NF2L1_HUMAN (1-772): 0: 903: 100.00		FBXW7_HUMAN (76-527): 7.38e-83: 276: 23.71
+	Mm
		1112907 NF2L2_MOUSE (162-762): 2.1e-162: 484: 35.19		FBW1A_MOUSE (1-605): 0: 547: 98.68
+	Hs
		1081265 NF2L2_HUMAN (162-762): 6.41e-153: 461: 32.55		FBW1A_HUMAN (1-605): 0: 551: 100.00
+	Hs
		1081259 NF2L2_HUMAN (162-762): 6.41e-153: 461: 32.55		FBW1B_HUMAN (96-605): 1.89e-143: 428: 85.69
+	Hs
		1083925 NFE2_HUMAN (289-759): 3.57e-65: 223: 30.36		FBW1A_HUMAN (1-605): 0: 551: 100.00
+	Hs
		1147427 CR3L3_HUMAN (422-729): 8.76e-48: 177: 17.83		FBW1A_HUMAN (1-605): 0: 551: 100.00
+	Hs
		1281509 NF2L3_HUMAN (208-770): 9.15e-124: 388: 34.76		FBXW7_HUMAN (76-527): 7.38e-83: 276: 23.71
+	Hs
		1147425 CR3L3_HUMAN (422-729): 8.76e-48: 177: 17.83		FBW1B_HUMAN (96-605): 1.89e-143: 428: 85.69
+	Hs
		402320 JUN_HUMAN (390-729): 1.67e-53: 190: 14.71		FBXW7_HUMAN (76-527): 7.38e-83: 276: 23.71
+	Mm
		991018 NFE2_MOUSE (289-759): 2.61e-73: 245: 31.64		PLRG1_MOUSE (417-604): 1.53e-38: 150: 23.47
+	Mm
		903658 NFE2_MOUSE (289-759): 2.61e-73: 245: 31.64		WDR5_MOUSE (458-605): 5.01e-38: 145: 25.33
+	Hs
		157156 BACH1_HUMAN (349-725): 2.96e-61: 221: 20.91		PLRG1_HUMAN (417-604): 2.83e-38: 150: 23.47
+	Hs
		402538 JUN_HUMAN (390-729): 1.67e-53: 190: 14.71		NLE1_HUMAN (33-408): 1.35e-41: 159: 13.21
+	Hs
		209378 JUN_HUMAN (390-729): 1.67e-53: 190: 14.71		PLRG1_HUMAN (417-604): 2.83e-38: 150: 23.47
+	Hs
		401754 JUN_HUMAN (390-729): 1.67e-53: 190: 14.71		WDR5_HUMAN (458-605): 5.01e-38: 145: 25.33
+	Hs
		196941 JUN_HUMAN (390-729): 1.67e-53: 190: 14.71		PRP4_HUMAN (387-594): 6.19e-35: 140: 23.66
+	Hs
		197114 MAFB_HUMAN (486-738): 2.78e-35: 138: 12.16		PRP4_HUMAN (387-594): 6.19e-35: 140: 23.66
+	Mm
		903672 MAFA_MOUSE (625-747): 1.32e-30: 125: 24.39		WDR5_MOUSE (458-605): 5.01e-38: 145: 25.33
+	Dm
		576069 JRA_DROME (451-722): 2.72e-38: 146: 17.75		EBI_DROME (500-605): 2.04e-16: 85: 18.42