HitPredict

Interactor 1: NF2L1 (Q14494)
Endoplasmic reticulum membrane sensor NFE2L1 (Locus control region-factor 1) (LCR-F1) (Nuclear factor erythroid 2-related factor 1) (NF-E2-related factor 1) (NFE2-related factor 1) (Nuclear factor, erythroid derived 2, like 1) (Protein NRF1, p120 form) (Transcription factor 11) (TCF-11) [Cleaved into: Transcription factor NRF1 (Protein NRF1, p110 form)]
Gene: NFE2L1

Interactor 2: MAFB (Q9Y5Q3)
Transcription factor MafB (Maf-B) (V-maf musculoaponeurotic fibrosarcoma oncogene homolog B)
Gene: MAFB

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.647

Property	Details
Experiments	20102225
Identification Methods	peptide array
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	bZIP_Maf~bZIP_Maf
Common GO terms	GO:0000785 - chromatin GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific GO:0005634 - nucleus GO:0006357 - regulation of transcription by RNA polymerase II
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 772 Hs			1 323
+	Hs
		1054297 NF2L1_HUMAN (1-772): 0: 903: 100.00		BACH2_HUMAN (40-313): 1.9e-54: 192: 15.28
+	Hs
		1054306 NF2L1_HUMAN (1-772): 0: 903: 100.00		NF2L3_HUMAN (114-322): 7.09e-49: 175: 18.06
+	Hs
		1054285 NF2L1_HUMAN (1-772): 0: 903: 100.00		NFE2_HUMAN (77-322): 2.35e-50: 173: 18.94
+	Hs
		1054283 NF2L1_HUMAN (1-772): 0: 903: 100.00		NF2L1_HUMAN (122-322): 1.14e-43: 161: 15.14
+	Hs
		401999 NF2L1_HUMAN (1-772): 0: 903: 100.00		JUN_HUMAN (103-309): 4.11e-36: 134: 15.94
+	Hs
		181928 NF2L1_HUMAN (1-772): 0: 903: 100.00		MAFG_HUMAN (186-320): 1.52e-36: 130: 45.93
+	Hs
		238462 NF2L1_HUMAN (1-772): 0: 903: 100.00		MAFK_HUMAN (184-320): 1.94e-35: 127: 50.37
+	Hs
		1054304 NF2L1_HUMAN (1-772): 0: 903: 100.00		MAFF_HUMAN (186-318): 2.81e-31: 116: 42.86
+	Mm
		873229 NF2L2_MOUSE (162-762): 2.1e-162: 484: 35.19		MAF_MOUSE (1-323): 8.05e-79: 246: 49.60
+	Hs
		265138 NF2L2_HUMAN (162-762): 6.41e-153: 461: 32.55		MAF_HUMAN (1-323): 2.7e-77: 242: 49.47
+	Hs
		1081266 NF2L2_HUMAN (162-762): 6.41e-153: 461: 32.55		NF2L3_HUMAN (114-322): 7.09e-49: 175: 18.06
+	Hs
		1081213 NF2L2_HUMAN (162-762): 6.41e-153: 461: 32.55		NFE2_HUMAN (77-322): 2.35e-50: 173: 18.94
+	Mm
		222377 NF2L2_MOUSE (162-762): 2.1e-162: 484: 35.19		MAFG_MOUSE (186-320): 4.8e-37: 132: 47.41
+	Mm
		1141391 NF2L2_MOUSE (162-762): 2.1e-162: 484: 35.19		MAFK_MOUSE (184-319): 1e-35: 128: 50.74
+	Rn
		222891 NF2L2_RAT (162-762): 3.19e-160: 479: 34.33		Q6IRI7_RAT (184-319): 2.03e-35: 127: 50.00
+	Hs
		402074 NF2L2_HUMAN (162-762): 6.41e-153: 461: 32.55		JUN_HUMAN (103-309): 4.11e-36: 134: 15.94
+	Hs
		181929 NF2L2_HUMAN (162-762): 6.41e-153: 461: 32.55		MAFG_HUMAN (186-320): 1.52e-36: 130: 45.93
+	Hs
		238464 NF2L2_HUMAN (162-762): 6.41e-153: 461: 32.55		MAFK_HUMAN (184-320): 1.94e-35: 127: 50.37
+	Hs
		1081262 NF2L2_HUMAN (162-762): 6.41e-153: 461: 32.55		MAFF_HUMAN (186-318): 2.81e-31: 116: 42.86
+	Ci
		100120 F6TNN0_CIOIN (169-766): 3.56e-127: 404: 23.20		F6WVZ0_CIOIN (211-313): 8.01e-31: 115: 46.60