HitPredict

Interactor 1: HLTF (Q14527)
Helicase-like transcription factor (EC 2.3.2.27) (EC 3.6.4.-) (DNA-binding protein/plasminogen activator inhibitor 1 regulator) (HIP116) (RING finger protein 80) (RING-type E3 ubiquitin transferase HLTF) (SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 3) (Sucrose nonfermenting protein 2-like 3)
Gene: HLTF

Interactor 2: UB2V2 (Q15819)
Ubiquitin-conjugating enzyme E2 variant 2 (DDVit 1) (Enterocyte differentiation-associated factor 1) (EDAF-1) (Enterocyte differentiation-promoting factor 1) (EDPF-1) (MMS2 homolog) (Vitamin D3-inducible protein)
Gene: UBE2V2

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.76	1.00	0.873

Property	Details
Experiments	22904075, 30696947, 18316726
Identification Methods	pull down, affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	UQ_con~zf-C3HC4_2
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0016567 - protein ubiquitination
Homologous interactions	15

Homologous interactions

Color coding for hit scores

	1 1009 Hs			1 145
+	Hs
		829001 HLTF_HUMAN (1-1009): 0: 945: 100.00		UBE2A_HUMAN (7-144): 6.23e-58: 178: 21.58
+	Hs
		927752 HLTF_HUMAN (1-1009): 0: 945: 100.00		UBE2B_HUMAN (7-144): 2.17e-57: 177: 20.86
+	Zm
		13331 A0A1D6GA59_MAIZE (157-1007): 3.06e-172: 538: 21.04		A0A1D6FSE0_MAIZE (9-144): 6.4e-59: 181: 24.82
+	Sp
		252628 RAD5_SCHPO (78-1008): 4.15e-162: 509: 21.34		MMS2_SCHPO (8-143): 8.26e-63: 190: 50.00
+	Zm
		26276 A0A1D6J209_MAIZE (123-910): 1.61e-159: 501: 16.26		A0A1D6LKH6_MAIZE (6-144): 3.12e-57: 177: 18.57
+	Hs
		930470 ARIP4_HUMAN (176-1006): 4.18e-144: 468: 15.88		UBC9_HUMAN (7-143): 1.02e-54: 170: 21.01
+	Sp
		194350 FFT3_SCHPO (316-994): 9.43e-144: 454: 19.49		UBC4_SCHPO (10-144): 1.59e-58: 180: 23.53
+	Hs
		930476 RA54B_HUMAN (298-1008): 5.69e-139: 441: 18.32		UBC9_HUMAN (7-143): 1.02e-54: 170: 21.01
+	Sc
		549844 ULS1_YEAST (468-1009): 1.74e-129: 431: 26.89		UBC4_YEAST (9-144): 3.56e-57: 176: 21.90
+	Hs
		163586 BTAF1_HUMAN (377-1007): 2.39e-115: 393: 19.76		UBE2A_HUMAN (7-144): 6.23e-58: 178: 21.58
+	Hs
		849332 SHPRH_HUMAN (758-970): 1.04e-18: 94.4: 29.41		UB2D1_HUMAN (10-145): 2.2e-59: 182: 24.82
+	Hs
		1061755 SHPRH_HUMAN (758-970): 1.04e-18: 94.4: 29.41		UB2V2_HUMAN (1-145): 4.36e-58: 178: 100.00
+	Hs
		829005 SHPRH_HUMAN (758-970): 1.04e-18: 94.4: 29.41		UBE2A_HUMAN (7-144): 6.23e-58: 178: 21.58
+	Hs
		927753 SHPRH_HUMAN (758-970): 1.04e-18: 94.4: 29.41		UBE2B_HUMAN (7-144): 2.17e-57: 177: 20.86
+	Dm
		283907 RAD54_DROME (823-982): 8.97e-21: 100: 36.88		UBCD2_DROME (30-122): 4.73e-12: 63: 30.85