HitPredict

Interactor 1: HLTF (Q14527)
Helicase-like transcription factor (EC 2.3.2.27) (EC 3.6.4.-) (DNA-binding protein/plasminogen activator inhibitor 1 regulator) (HIP116) (RING finger protein 80) (RING-type E3 ubiquitin transferase HLTF) (SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 3) (Sucrose nonfermenting protein 2-like 3)
Gene: HLTF

Interactor 2: H2B1A (Q96A08)
Histone H2B type 1-A (Histone H2B, testis) (TSH2B.1) (hTSH2B) (Testis-specific histone H2B)
Gene: H2BC1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.74	1.00	0.861

Property	Details
Experiments	26186194, 28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Histone~SNF2-rel_dom, Histone~zf-C3HC4_2
Common GO terms	GO:0003677 - DNA binding GO:0005634 - nucleus GO:0005654 - nucleoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1009 Hs			1 127
+	Hs
		1055124 HLTF_HUMAN (1-1009): 0: 945: 100.00		H2B2E_HUMAN (1-127): 4.39e-54: 167: 85.83
+	Hs
		707628 HLTF_HUMAN (1-1009): 0: 945: 100.00		H2B1B_HUMAN (1-127): 6.87e-54: 166: 85.83
+	Hs
		707647 CHD9_HUMAN (80-918): 3.62e-159: 523: 15.03		H2B1B_HUMAN (1-127): 6.87e-54: 166: 85.83
+	Hs
		846990 SMCA4_HUMAN (94-918): 4.65e-157: 507: 15.16		H2B2E_HUMAN (1-127): 4.39e-54: 167: 85.83
+	Hs
		846915 SMCA4_HUMAN (94-918): 4.65e-157: 507: 15.16		H2B1C_HUMAN (1-127): 8.19e-54: 166: 85.04
+	Hs
		846736 SMCA2_HUMAN (94-909): 4.19e-152: 492: 14.90		H2B1C_HUMAN (1-127): 8.19e-54: 166: 85.04
+	Hs
		1087449 CHD7_HUMAN (176-918): 5.1e-148: 490: 14.74		H2B2E_HUMAN (1-127): 4.39e-54: 167: 85.83
+	Hs
		707773 CHD7_HUMAN (176-918): 5.1e-148: 490: 14.74		H2B1B_HUMAN (1-127): 6.87e-54: 166: 85.83
+	Hs
		918744 CHD7_HUMAN (176-918): 5.1e-148: 490: 14.74		H2B1C_HUMAN (1-127): 8.19e-54: 166: 85.04
+	Hs
		846844 SMCA2_HUMAN (94-909): 4.19e-152: 492: 14.90		H2B1A_HUMAN (1-127): 1.72e-52: 163: 100.00
+	Hs
		918719 HELLS_HUMAN (241-1009): 3.24e-156: 484: 18.88		H2B1C_HUMAN (1-127): 8.19e-54: 166: 85.04
+	Hs
		918686 SMRCD_HUMAN (193-1009): 1.61e-152: 480: 18.47		H2B1C_HUMAN (1-127): 8.19e-54: 166: 85.04
+	Hs
		229415 SMCA5_HUMAN (288-928): 7.49e-149: 471: 16.11		H2B2E_HUMAN (1-127): 4.39e-54: 167: 85.83
+	Hs
		229321 SMCA5_HUMAN (288-928): 7.49e-149: 471: 16.11		H2B1B_HUMAN (1-127): 6.87e-54: 166: 85.83
+	Hs
		229353 SMCA5_HUMAN (288-928): 7.49e-149: 471: 16.11		H2B1C_HUMAN (1-127): 8.19e-54: 166: 85.04
+	Hs
		229458 SMCA5_HUMAN (288-928): 7.49e-149: 471: 16.11		H2B1H_HUMAN (5-127): 5.52e-54: 166: 85.37
+	Sc
		355822 BTAF1_YEAST (378-1005): 4.08e-143: 472: 20.71		H2B2_YEAST (4-126): 4.46e-41: 134: 69.36
+	Sp
		194285 FFT3_SCHPO (316-994): 9.43e-144: 454: 19.49		H2B1_SCHPO (5-126): 8.55e-46: 146: 69.67
+	Sc
		355819 RAD16_YEAST (272-1005): 6.76e-143: 448: 23.59		H2B2_YEAST (4-126): 4.46e-41: 134: 69.36
+	Sc
		355821 FUN30_YEAST (409-992): 1.04e-136: 441: 23.25		H2B2_YEAST (4-126): 4.46e-41: 134: 69.36