HitPredict

Interactor 1: HLTF (Q14527)
Helicase-like transcription factor (EC 2.3.2.27) (EC 3.6.4.-) (DNA-binding protein/plasminogen activator inhibitor 1 regulator) (HIP116) (RING finger protein 80) (RING-type E3 ubiquitin transferase HLTF) (SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 3) (Sucrose nonfermenting protein 2-like 3)
Gene: HLTF

Interactor 2: TF7L2 (Q9NQB0)
Transcription factor 7-like 2 (HMG box transcription factor 4) (T-cell-specific transcription factor 4) (T-cell factor 4) (TCF-4) (hTCF-4)
Gene: TCF7L2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	30833792
Identification Methods	affinity chromatography technology, pull down
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0045944 - positive regulation of transcription by RNA polymerase II
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1009 Hs			1 619
+	Hs
		1055155 HLTF_HUMAN (1-1009): 0: 945: 100.00		CIC_HUMAN (43-578): 1.85e-33: 139: 15.01
+	Hs
		847069 SMCA4_HUMAN (94-918): 4.65e-157: 507: 15.16		SOX7_HUMAN (317-610): 3.06e-44: 164: 18.27
+	Hs
		846730 SMCA2_HUMAN (94-909): 4.19e-152: 492: 14.90		SOX10_HUMAN (312-612): 6.86e-48: 176: 17.10
+	Hs
		881831 CHD7_HUMAN (176-918): 5.1e-148: 490: 14.74		SOX10_HUMAN (312-612): 6.86e-48: 176: 17.10
+	Hs
		846863 SMCA2_HUMAN (94-909): 4.19e-152: 492: 14.90		SOX7_HUMAN (317-610): 3.06e-44: 164: 18.27
+	Hs
		1311936 CHD7_HUMAN (176-918): 5.1e-148: 490: 14.74		SOX7_HUMAN (317-610): 3.06e-44: 164: 18.27
+	Mm
		1111947 SMCA4_MOUSE (94-909): 8.84e-157: 505: 15.13		NSD2_MOUSE (251-564): 4.12e-34: 141: 13.97
+	Hs
		847058 SMCA4_HUMAN (94-918): 4.65e-157: 507: 15.16		CIC_HUMAN (43-578): 1.85e-33: 139: 15.01
+	Hs
		727814 CHD7_HUMAN (176-918): 5.1e-148: 490: 14.74		SOX5_HUMAN (3-485): 3.95e-38: 152: 12.73
+	Hs
		818102 CHD9_HUMAN (80-918): 3.62e-159: 523: 15.03		SOX2_HUMAN (316-613): 5.49e-27: 113: 15.69
+	Hs
		1300971 CHD7_HUMAN (176-918): 5.1e-148: 490: 14.74		CIC_HUMAN (43-578): 1.85e-33: 139: 15.01
+	Hs
		727934 CHD7_HUMAN (176-918): 5.1e-148: 490: 14.74		SOX6_HUMAN (85-501): 1.65e-33: 138: 11.66
+	Hs
		846944 SMCA4_HUMAN (94-918): 4.65e-157: 507: 15.16		SSRP1_HUMAN (333-511): 2.38e-26: 116: 18.89
+	Hs
		817810 SMCA4_HUMAN (94-918): 4.65e-157: 507: 15.16		SOX2_HUMAN (316-613): 5.49e-27: 113: 15.69
+	Mm
		818702 SMCA4_MOUSE (94-909): 8.84e-157: 505: 15.13		SOX2_MOUSE (318-613): 2.17e-26: 111: 14.15
+	Hs
		817809 SMCA2_HUMAN (94-909): 4.19e-152: 492: 14.90		SOX2_HUMAN (316-613): 5.49e-27: 113: 15.69
+	Mm
		57186 CHD7_MOUSE (152-918): 1.74e-148: 492: 15.20		Q60I23_MOUSE (318-613): 2.23e-26: 111: 14.47
+	Hs
		818550 CHD7_HUMAN (176-918): 5.1e-148: 490: 14.74		SOX2_HUMAN (316-613): 5.49e-27: 113: 15.69
+	Hs
		846943 SMCA4_HUMAN (94-918): 4.65e-157: 507: 15.16		SOX4_HUMAN (349-420): 8.6e-16: 82.5: 33.33
+	Hs
		846868 SMCA2_HUMAN (94-909): 4.19e-152: 492: 14.90		SOX17_HUMAN (350-432): 1.18e-14: 78.2: 31.33