HitPredict

Interactor 1: HNF4G (Q14541)
Hepatocyte nuclear factor 4-gamma (HNF-4-gamma) (Nuclear receptor subfamily 2 group A member 2)
Gene: HNF4G

Interactor 2: NCOA1 (Q15788)
Nuclear receptor coactivator 1 (NCoA-1) (EC 2.3.1.48) (Class E basic helix-loop-helix protein 74) (bHLHe74) (Protein Hin-2) (RIP160) (Renal carcinoma antigen NY-REN-52) (Steroid receptor coactivator 1) (SRC-1)
Gene: NCOA1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.56	1.00	0.754

Property	Details
Experiments	15604093, 23975195
Identification Methods	two hybrid
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	Hormone_recep~SRC-1
Common GO terms	GO:0000785 - chromatin GO:0005654 - nucleoplasm GO:0005829 - cytosol GO:0045944 - positive regulation of transcription by RNA polymerase II
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 408 Hs			1 1441
+	Hs
		782555 HNF4A_HUMAN (3-397): 2.74e-137: 402: 73.40		NCOA1_HUMAN (1-1441): 3.28e-155: 509: 100.00
+	Hs
		587177 RXRA_HUMAN (5-332): 5.69e-118: 353: 40.90		NCOA1_HUMAN (1-1441): 3.28e-155: 509: 100.00
+	Hs
		659718 RXRB_HUMAN (7-328): 7.6e-115: 347: 42.12		NCOA1_HUMAN (1-1441): 3.28e-155: 509: 100.00
+	Hs
		500364 RARB_HUMAN (10-373): 2.2e-110: 333: 26.26		NCOA1_HUMAN (1-1441): 3.28e-155: 509: 100.00
+	Hs
		782560 HNF4A_HUMAN (3-397): 2.74e-137: 402: 73.40		HIF1A_HUMAN (8-798): 3.33e-103: 351: 13.33
+	Hs
		126108 HNF4A_HUMAN (3-397): 2.74e-137: 402: 73.40		BMAL1_HUMAN (1-539): 2.88e-105: 350: 16.16
+	Mm
		985528 HNF4G_MOUSE (1-408): 5.9e-159: 455: 95.83		Q05BA5_MOUSE (1-1411): 1.11e-76: 282: 23.77
+	Mm
		60499 HNF4G_MOUSE (1-408): 5.9e-159: 455: 95.83		A5D6Q2_MOUSE (48-1411): 3.96e-70: 261: 22.54
+	Hs
		126103 RXRA_HUMAN (5-332): 5.69e-118: 353: 40.90		BMAL1_HUMAN (1-539): 2.88e-105: 350: 16.16
+	Hs
		782708 HNF4A_HUMAN (3-397): 2.74e-137: 402: 73.40		NCOA3_HUMAN (1-1343): 5.25e-75: 277: 24.33
+	Hs
		649056 HNF4A_HUMAN (3-397): 2.74e-137: 402: 73.40		ARNT_HUMAN (1-642): 5.73e-69: 250: 16.45
+	Dm
		836362 HNF4_DROME (9-375): 2.98e-118: 361: 60.42		SIMA_DROME (10-822): 7.59e-78: 286: 14.25
+	Hs
		587212 RXRA_HUMAN (5-332): 5.69e-118: 353: 40.90		NCOA3_HUMAN (1-1343): 5.25e-75: 277: 24.33
+	Hs
		181498 RXRA_HUMAN (5-332): 5.69e-118: 353: 40.90		CLOCK_HUMAN (5-833): 1.42e-75: 271: 14.15
+	Hs
		490089 COT1_HUMAN (3-335): 1.69e-108: 327: 34.90		AHR_HUMAN (2-833): 8.86e-80: 284: 13.86
+	Hs
		500381 RARB_HUMAN (10-373): 2.2e-110: 333: 26.26		NCOA3_HUMAN (1-1343): 5.25e-75: 277: 24.33
+	Hs
		782551 HNF4A_HUMAN (3-397): 2.74e-137: 402: 73.40		NCOA2_HUMAN (496-1439): 2.6e-11: 70.7: 9.43
+	Hs
		587173 RXRA_HUMAN (5-332): 5.69e-118: 353: 40.90		NCOA2_HUMAN (496-1439): 2.6e-11: 70.7: 9.43
+	Hs
		587195 RXRA_HUMAN (5-332): 5.69e-118: 353: 40.90		NPAS2_HUMAN (29-210): 2.08e-09: 64.3: 29.73
+	Hs
		490101 COT1_HUMAN (3-335): 1.69e-108: 327: 34.90		NCOA2_HUMAN (496-1439): 2.6e-11: 70.7: 9.43