HitPredict

Interactor 1: HNF4G (Q14541)
Hepatocyte nuclear factor 4-gamma (HNF-4-gamma) (Nuclear receptor subfamily 2 group A member 2)
Gene: HNF4G

Interactor 2: NSD1 (Q96L73)
Histone-lysine N-methyltransferase, H3 lysine-36 specific (EC 2.1.1.357) (Androgen receptor coactivator 267 kDa protein) (Androgen receptor-associated protein of 267 kDa) (H3-K36-HMTase) (Lysine N-methyltransferase 3B) (Nuclear receptor-binding SET domain-containing protein 1) (NR-binding SET domain-containing protein)
Gene: NSD1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.481

Property	Details
Experiments	23975195
Identification Methods	two hybrid
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000785 - chromatin GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding GO:0005654 - nucleoplasm GO:0008270 - zinc ion binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 408 Hs			1 2696
+	Hs
		587193 RXRA_HUMAN (5-332): 5.69e-118: 353: 40.90		NSD1_HUMAN (1-2696): 0: 3408: 100.00
+	Hs
		490110 COT1_HUMAN (3-335): 1.69e-108: 327: 34.90		NSD1_HUMAN (1-2696): 0: 3408: 100.00
+	Hs
		622823 COT2_HUMAN (4-335): 3.56e-106: 321: 35.29		NSD1_HUMAN (1-2696): 0: 3408: 100.00
+	Hs
		370224 ESR1_HUMAN (1-367): 1.12e-99: 310: 24.40		NSD1_HUMAN (1-2696): 0: 3408: 100.00
+	Mm
		93747 RXRA_MOUSE (5-328): 7.85e-119: 355: 41.39		E9QAE4_MOUSE (1-2696): 0: 3312: 83.71
+	Hs
		782659 HNF4A_HUMAN (3-397): 2.74e-137: 402: 73.40		EHMT1_HUMAN (1781-2098): 2.45e-65: 247: 20.29
+	Hs
		782635 HNF4A_HUMAN (3-397): 2.74e-137: 402: 73.40		EHMT2_HUMAN (1826-2080): 8.77e-63: 239: 22.49
+	Hs
		782557 HNF4A_HUMAN (3-397): 2.74e-137: 402: 73.40		EZH2_HUMAN (1883-2067): 7.8e-59: 220: 29.80
+	Hs
		203613 ESR1_HUMAN (1-367): 1.12e-99: 310: 24.40		SUV91_HUMAN (1705-2081): 6.86e-87: 293: 21.86
+	Hs
		331692 ESR1_HUMAN (1-367): 1.12e-99: 310: 24.40		NSD2_HUMAN (162-430): 3.61e-72: 270: 24.63
+	Hs
		370465 ESR1_HUMAN (1-367): 1.12e-99: 310: 24.40		EHMT1_HUMAN (1781-2098): 2.45e-65: 247: 20.29
+	Hs
		500366 RARB_HUMAN (10-373): 2.2e-110: 333: 26.26		EZH2_HUMAN (1883-2067): 7.8e-59: 220: 29.80
+	Hs
		370370 ESR1_HUMAN (1-367): 1.12e-99: 310: 24.40		SETD2_HUMAN (1790-2119): 9.55e-63: 241: 27.98
+	Hs
		370223 ESR1_HUMAN (1-367): 1.12e-99: 310: 24.40		EHMT2_HUMAN (1826-2080): 8.77e-63: 239: 22.49
+	Hs
		370371 ESR1_HUMAN (1-367): 1.12e-99: 310: 24.40		NSD3_HUMAN (130-430): 6.42e-60: 231: 24.92
+	Hs
		369688 ESR1_HUMAN (1-367): 1.12e-99: 310: 24.40		EZH2_HUMAN (1883-2067): 7.8e-59: 220: 29.80
+	Hs
		782595 HNF4A_HUMAN (3-397): 2.74e-137: 402: 73.40		KMT2C_HUMAN (2086-2261): 7.67e-10: 67.3: 13.44
+	Hs
		152605 HNF4A_HUMAN (3-397): 2.74e-137: 402: 73.40		KMT2D_HUMAN (1011-1538): 2.41e-09: 65.8: 8.69
+	Hs
		370040 ESR1_HUMAN (1-367): 1.12e-99: 310: 24.40		KMT2C_HUMAN (2086-2261): 7.67e-10: 67.3: 13.44
+	Hs
		152573 ESR1_HUMAN (1-367): 1.12e-99: 310: 24.40		KMT2D_HUMAN (1011-1538): 2.41e-09: 65.8: 8.69