HitPredict

Interactor 1: ITPR1 (Q14643)
Inositol 1,4,5-trisphosphate-gated calcium channel ITPR1 (IP3 receptor isoform 1) (IP3R 1) (InsP3R1) (Inositol 1,4,5 trisphosphate receptor) (Inositol 1,4,5-trisphosphate receptor type 1) (Type 1 inositol 1,4,5-trisphosphate receptor) (Type 1 InsP3 receptor)
Gene: ITPR1

Interactor 2: CABP1 (Q9NZU7)
Calcium-binding protein 1 (CaBP1) (Calbrain) (Caldendrin)
Gene: CABP1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.66	1.00	0.812

Property	Details
Experiments	14685260, 12032348
Identification Methods	affinity chromatography technology, pull down
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	EF-hand_7~Ion_trans
Common GO terms	GO:0005509 - calcium ion binding GO:0005886 - plasma membrane GO:0014069 - postsynaptic density GO:0048471 - perinuclear region of cytoplasm
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 2758 Hs			1 370
+	Hs
		1056323 ITPR1_HUMAN (1-2758): 0: 4494: 100.00		CABP2_HUMAN (208-370): 2.51e-73: 228: 73.62
+	Hs
		648503 ITPR1_HUMAN (1-2758): 0: 4494: 100.00		CALL3_HUMAN (228-293): 1.36e-20: 88.9: 33.33
+	Hs
		1055712 ITPR2_HUMAN (1-2751): 0: 4139: 68.18		CABP2_HUMAN (208-370): 2.51e-73: 228: 73.62
+	Hs
		484125 ITPR2_HUMAN (1-2751): 0: 4139: 68.18		CALM3_HUMAN (301-370): 1.22e-18: 83.7: 40.00
+	Hs
		361217 ITPR2_HUMAN (1-2751): 0: 4139: 68.18		TNNC2_HUMAN (304-370): 9.91e-09: 55.8: 43.28
+	Hs
		1055801 ITPR3_HUMAN (4-2744): 0: 3845: 60.94		CABP2_HUMAN (208-370): 2.51e-73: 228: 73.62
+	Hs
		648502 ITPR3_HUMAN (4-2744): 0: 3845: 60.94		CALL3_HUMAN (228-293): 1.36e-20: 88.9: 33.33
+	Hs
		484126 ITPR3_HUMAN (4-2744): 0: 3845: 60.94		CALM3_HUMAN (301-370): 1.22e-18: 83.7: 40.00
+	Hs
		361218 ITPR3_HUMAN (4-2744): 0: 3845: 60.94		TNNC2_HUMAN (304-370): 9.91e-09: 55.8: 43.28
+	Dm
		906671 RYR_DROME (1679-2262): 3.44e-57: 223: 20.00		CALM_DROME (301-370): 1.38e-18: 83.3: 40.00