Interactor 1: IRF3 (Q14653)
Interferon regulatory factor 3 (IRF-3)
Gene: IRF3

Interactor 2: IRF3 (Q14653)
Interferon regulatory factor 3 (IRF-3)
Gene: IRF3

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.99 1.00 0.996

The method score is based on:

Property Details
Experiments 12473110, 25636800, 26347139, 26456228, 26407194, 26221961, 23986588, 27956528, 30770245, 24016850, 31308089, 32476569, 18309294, 34084167, 35103914, 19454348, 19893624, 22114345, 22588174, 21782231 and 32 others

more...

Identification Methods affinity chromatography technology, protein complementation assay, pull down, comigration in non denaturing gel electrophoresis, anti tag coimmunoprecipitation, polymerization, blue native page, tandem affinity purification, cosedimentation in solution, molecular sieving and 1 others

more...

Interaction Type physical association, direct interaction, association

The annotation score is based on:

Property Details
Interacting Pfam domains IRF~IRF, IRF-3~IRF-3
Common GO terms GO:0000785 - chromatin
GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001216 - DNA-binding transcription activator activity
GO:0001227 - DNA-binding transcription repressor activity, RNA polymerase II-specific
and 42 others

more...

Homologous interactions 17

Homologous interactions

Color coding for hit scores

1 427
Hs

1 427
+ Mm
+ Hs
+ Hs
+ Hs
+ Mm
+ Hs
+ Mm
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Mm
+ Hs
+ Hs
+ Hs

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024