Interactor 1: IRF3 (Q14653)
Interferon regulatory factor 3 (IRF-3)
Gene: IRF3

Interactor 2: STING (Q86WV6)
Stimulator of interferon genes protein (hSTING) (Endoplasmic reticulum interferon stimulator) (ERIS) (Mediator of IRF3 activation) (hMITA) (Transmembrane protein 173)
Gene: STING1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.90 0.60 0.739

The method score is based on:

Property Details
Experiments 25636800, 30018345, 37130168, 33086059, 24622840, 18818105, 22394562
Identification Methods affinity chromatography technology, anti tag coimmunoprecipitation, pull down
Interaction Type physical association

The annotation score is based on:

Property Details
Interacting Pfam domains -
Common GO terms GO:0002753 - cytoplasmic pattern recognition receptor signaling pathway
GO:0005654 - nucleoplasm
GO:0005829 - cytosol
GO:0032481 - positive regulation of type I interferon production
GO:0032728 - positive regulation of interferon-beta production
and 9 others

more...

Homologous interactions 2

Homologous interactions

Color coding for hit scores

1 427
Hs

1 379
+ Mm
+ Hs

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024