HitPredict

Interactor 1: IRF3 (Q14653)
Interferon regulatory factor 3 (IRF-3)
Gene: IRF3

Interactor 2: TCAM1 (Q8IUC6)
TIR domain-containing adapter molecule 1 (TICAM-1) (Proline-rich, vinculin and TIR domain-containing protein B) (Putative NF-kappa-B-activating protein 502H) (Toll-interleukin-1 receptor domain-containing adapter protein inducing interferon beta) (MyD88-3) (TIR domain-containing adapter protein inducing IFN-beta)
Gene: TICAM1

Species: Homo sapiens

Source: innatedb

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.76	0.60	0.676

The method score is based on:

Property	Details
Experiments	25636800, 12471095, 16281057, 14739303
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association

The annotation score is based on:

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005739 - mitochondrion GO:0005829 - cytosol GO:0031663 - lipopolysaccharide-mediated signaling pathway GO:0032481 - positive regulation of type I interferon production GO:0032728 - positive regulation of interferon-beta production and 6 others more... GO:0034142 - toll-like receptor 4 signaling pathway GO:0035666 - TRIF-dependent toll-like receptor signaling pathway GO:0043123 - positive regulation of canonical NF-kappaB signal transduction GO:0045087 - innate immune response GO:0051607 - defense response to virus GO:1900017 - positive regulation of cytokine production involved in inflammatory response
Homologous interactions	2

Homologous interactions

Color coding for hit scores

	1	427
Hs

1	712

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024