HitPredict

Interactor 1: IRF3 (Q14653)
Interferon regulatory factor 3 (IRF-3)
Gene: IRF3

Interactor 2: CBP (Q92793)
CREB-binding protein (Histone lysine acetyltransferase CREBBP) (EC 2.3.1.48) (Protein lactyltransferas CREBBP) (EC 2.3.1.-) (Protein-lysine acetyltransferase CREBBP) (EC 2.3.1.-)
Gene: CREBBP

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.98 1.00 0.993

The method score is based on:

Property Details
Experiments 25733689, 10521456, 26773386, 21903422, 9488451, 15107417, 17761676, 17126870, 9660935, 16154084, 15582653, 12473110, 23824799, 18309294, 37023208, 9566918, 17015689, 10082512, 17296604, 17138826 and 8 others

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Identification Methods affinity chromatography technology, x-ray crystallography, pull down, cosedimentation in solution, ion exchange chromatography, molecular sieving, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, electrophoretic mobility supershift assay, coimmunoprecipitation
Interaction Type physical association, association, direct interaction

The annotation score is based on:

Property Details
Interacting Pfam domains Creb_binding~IRF-3
Common GO terms GO:0000785 - chromatin
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0005737 - cytoplasm
GO:0005829 - cytosol
and 1 others

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Homologous interactions 17

Homologous interactions

Color coding for hit scores

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Hs

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Last updated: 15 Jul 2024