HitPredict

Interactor 1: MDC1 (Q14676)
Mediator of DNA damage checkpoint protein 1 (Nuclear factor with BRCT domains 1)
Gene: MDC1

Interactor 2: CPSF6 (Q16630)
Cleavage and polyadenylation specificity factor subunit 6 (Cleavage and polyadenylation specificity factor 68 kDa subunit) (CPSF 68 kDa subunit) (Cleavage factor Im complex 68 kDa subunit) (CFIm68) (Pre-mRNA cleavage factor Im 68 kDa subunit) (Protein HPBRII-4/7)
Gene: CPSF6

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.60	0.584

Property	Details
Experiments	29656893, 22990118
Identification Methods	proximity labelling technology, affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 2089 Hs			1 551
+	Hs
		1056974 MDC1_HUMAN (1-2089): 0: 665: 100.00		WDR33_HUMAN (180-396): 5.21e-09: 61.5: 24.69
+	Hs
		1018972 TP53B_HUMAN (166-1970): 5.58e-75: 280: 8.87		CPSF6_HUMAN (1-520): 3.7e-92: 294: 100.00
+	Hs
		1019023 TP53B_HUMAN (166-1970): 5.58e-75: 280: 8.87		CPSF7_HUMAN (1-525): 3.55e-48: 175: 40.82
+	Hs
		801032 KI67_HUMAN (38-1868): 2.43e-65: 249: 11.53		SMCA2_HUMAN (179-551): 2.13e-47: 180: 14.93
+	Hs
		1084668 SRRM2_HUMAN (133-1326): 2.15e-19: 98.4: 8.08		CPSF6_HUMAN (1-520): 3.7e-92: 294: 100.00
+	Dm
		631333 ELYS_DROME (97-1204): 2.21e-43: 177: 11.82		BRM_DROME (249-551): 1.19e-45: 175: 20.72
+	Hs
		801346 KI67_HUMAN (38-1868): 2.43e-65: 249: 11.53		DIDO1_HUMAN (164-416): 4.81e-09: 61.5: 21.59
+	Dm
		631331 Q9VUB7_DROME (1842-2077): 2e-27: 124: 23.79		BRM_DROME (249-551): 1.19e-45: 175: 20.72
+	Hs
		311797 TACC2_HUMAN (151-1928): 1.23e-24: 115: 9.64		SMCA2_HUMAN (179-551): 2.13e-47: 180: 14.93
+	Dm
		1373616 Q9VUB7_DROME (1842-2077): 2e-27: 124: 23.79		CPSF6_DROME (8-485): 1.09e-43: 166: 36.97
+	Hs
		1173233 PAXI1_HUMAN (1840-2081): 6.55e-55: 212: 27.56		WDR33_HUMAN (180-396): 5.21e-09: 61.5: 24.69
+	Hs
		1031405 TITIN_HUMAN (175-1895): 2.81e-32: 141: 8.72		PABP4_HUMAN (81-517): 7.23e-31: 129: 13.51
+	Hs
		516609 TITIN_HUMAN (175-1895): 2.81e-32: 141: 8.72		PABP1_HUMAN (81-518): 2.46e-24: 109: 16.40
+	Hs
		516749 SRRM2_HUMAN (133-1326): 2.15e-19: 98.4: 8.08		PABP1_HUMAN (81-518): 2.46e-24: 109: 16.40
+	Hs
		516766 PRC2C_HUMAN (145-1944): 8.04e-16: 86.5: 8.07		PABP1_HUMAN (81-518): 2.46e-24: 109: 16.40
+	Hs
		965152 ANK2_HUMAN (608-1849): 1.3e-11: 72.7: 10.40		PABP3_HUMAN (82-518): 1.28e-22: 103: 15.56
+	Mm
		1351630 PCLO_MOUSE (75-1749): 3.3e-11: 71.5: 7.45		PCLO_MOUSE (195-468): 6.01e-14: 77.6: 11.31
+	Dm
		113976 M9PB30_DROME (131-695): 8.03e-11: 70.2: 6.81		M9PB30_DROME (190-412): 1.36e-12: 73: 16.67