HitPredict

Interactor 1: EPN4 (Q14677)
Clathrin interactor 1 (Clathrin-interacting protein localized in the trans-Golgi region) (Clint) (Enthoprotin) (Epsin-4) (Epsin-related protein) (EpsinR)
Gene: CLINT1

Interactor 2: REPS1 (Q96D71)
RalBP1-associated Eps domain-containing protein 1 (RalBP1-interacting protein 1)
Gene: REPS1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.65	0.60	0.628

Property	Details
Experiments	28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005654 - nucleoplasm GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0006897 - endocytosis GO:0043231 - intracellular membrane-bounded organelle
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 625 Hs			1 796
+	Hs
		1223707 ENTD1_HUMAN (9-190): 2.19e-76: 256: 38.42		REPS1_HUMAN (1-796): 2.33e-108: 351: 100.00
+	Hs
		1244792 EPN1_HUMAN (8-529): 2.46e-67: 231: 23.55		REPS2_HUMAN (4-796): 3.9e-87: 291: 32.23
+	Hs
		787913 EPN4_HUMAN (1-625): 2.12e-141: 426: 100.00		EPS15_HUMAN (4-782): 1.98e-17: 89.3: 10.12
+	Dm
		91160 Q7KU90_DROME (6-624): 1.54e-65: 232: 21.07		E3CTP7_DROME (1-695): 1.93e-74: 260: 11.95
+	Hs
		1353935 EPN1_HUMAN (8-529): 2.46e-67: 231: 23.55		EP15R_HUMAN (8-735): 2e-72: 256: 13.93
+	Sc
		710409 ENT1_YEAST (8-250): 7.46e-68: 229: 27.98		EDE1_YEAST (6-790): 4.29e-60: 223: 16.08
+	Ce
		1229391 Q9BI72_CAEEL (7-469): 1.25e-79: 261: 21.50		Q8MYM6_CAEEL (255-552): 5.22e-39: 151: 22.54
+	Sc
		692257 ENT1_YEAST (8-250): 7.46e-68: 229: 27.98		PAN1_YEAST (6-778): 8.78e-46: 179: 13.43
+	Hs
		1349324 EPN1_HUMAN (8-529): 2.46e-67: 231: 23.55		EHD2_HUMAN (256-370): 1e-40: 159: 33.91
+	Hs
		1331796 EPN1_HUMAN (8-529): 2.46e-67: 231: 23.55		EHD1_HUMAN (269-370): 3.03e-40: 157: 38.24
+	Mm
		1194350 EPN1_MOUSE (8-529): 2.71e-64: 223: 24.30		EHD2_MOUSE (247-379): 4.19e-41: 160: 31.58
+	Mm
		1194352 EPN1_MOUSE (8-529): 2.71e-64: 223: 24.30		EHD1_MOUSE (269-370): 3.15e-40: 157: 38.24
+	Hs
		1328941 EPN3_HUMAN (8-564): 8.6e-59: 210: 20.51		EHD2_HUMAN (256-370): 1e-40: 159: 33.91
+	Hs
		1328938 EPN3_HUMAN (8-564): 8.6e-59: 210: 20.51		EHD1_HUMAN (269-370): 3.03e-40: 157: 38.24
+	Ce
		1259347 Q9BI72_CAEEL (7-469): 1.25e-79: 261: 21.50		Q8WSP1_CAEEL (4-110): 1.59e-19: 95.4: 15.89
+	Ce
		1308345 Q9BI72_CAEEL (7-469): 1.25e-79: 261: 21.50		Q9U2T9_CAEEL (1-119): 4.74e-11: 68.9: 16.41
+	Ce
		1308343 Q9BI71_CAEEL (7-469): 5.67e-79: 259: 21.21		Q9U2T9_CAEEL (1-119): 4.74e-11: 68.9: 16.41
+	Hs
		787997 EPN1_HUMAN (8-529): 2.46e-67: 231: 23.55		EPS15_HUMAN (4-782): 1.98e-17: 89.3: 10.12
+	Mm
		1194353 EPN1_MOUSE (8-529): 2.71e-64: 223: 24.30		ITSN1_MOUSE (3-100): 1.25e-15: 83.9: 19.39
+	Hs
		787969 EPN3_HUMAN (8-564): 8.6e-59: 210: 20.51		EPS15_HUMAN (4-782): 1.98e-17: 89.3: 10.12