HitPredict

Interactor 1: G5ED33 (G5ED33)
Epidermal growth factor receptor pathway substrate 8 splice variant A (SH3 domain-containing protein)
Gene: eps-8

Interactor 2: Q9U2T9 (Q9U2T9)
Intersectin-1
Gene: itsn-1

Species: Caenorhabditis elegans

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.59	1.00	0.768

Property	Details
Experiments	18298590, 23549480
Identification Methods	two hybrid
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	SH3_1~SH3_2, SH3_2~SH3_2, SH3_2~SH3_9
Common GO terms	GO:0005886 - plasma membrane
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 917 Ce			1 1085
+	Hs
		1020402 EPS8_HUMAN (45-914): 0: 671: 25.19		ITSN2_HUMAN (475-1085): 1.13e-26: 120: 14.82
+	Hs
		924530 EPS8_HUMAN (45-914): 0: 671: 25.19		GRB2_HUMAN (1030-1085): 4.24e-13: 71.7: 33.33
+	Hs
		787862 CRKL_HUMAN (583-731): 3.06e-34: 135: 19.08		EPS15_HUMAN (4-576): 1.54e-61: 229: 18.12
+	Hs
		277020 STAM2_HUMAN (551-908): 4.06e-32: 133: 10.42		EPS15_HUMAN (4-576): 1.54e-61: 229: 18.12
+	Hs
		208989 NCK2_HUMAN (499-845): 1.35e-60: 212: 9.59		NCK1_HUMAN (887-1082): 7.16e-35: 139: 22.27
+	Hs
		557629 NCK1_HUMAN (605-851): 3.91e-26: 113: 12.06		EPS15_HUMAN (4-576): 1.54e-61: 229: 18.12
+	Dm
		91151 M9ND00_DROME (435-671): 2.43e-28: 125: 10.50		E3CTP7_DROME (5-492): 4.03e-56: 211: 19.41
+	Hs
		208958 NCK2_HUMAN (499-845): 1.35e-60: 212: 9.59		NCK2_HUMAN (660-960): 3.34e-25: 110: 18.69
+	Cl
		47357 F1PHV6_CANLF (503-670): 6.86e-17: 88.2: 12.43		A0A8I3PJA6_CANLF (4-534): 1.36e-60: 226: 19.93
+	Hs
		173587 NPHP1_HUMAN (460-813): 2.9e-36: 149: 16.90		SH319_HUMAN (722-1084): 1.39e-34: 144: 18.88
+	Hs
		208967 NCK2_HUMAN (499-845): 1.35e-60: 212: 9.59		SRBS2_HUMAN (890-1084): 1.68e-09: 64.3: 27.20
+	Hs
		557594 NCK1_HUMAN (605-851): 3.91e-26: 113: 12.06		NCK1_HUMAN (887-1082): 7.16e-35: 139: 22.27
+	Hs
		548690 BTK_HUMAN (461-719): 4.75e-40: 160: 12.81		VAV_HUMAN (901-1084): 4.39e-16: 85.6: 19.91
+	Hs
		924503 BTK_HUMAN (461-719): 4.75e-40: 160: 12.81		GRB2_HUMAN (1030-1085): 4.24e-13: 71.7: 33.33
+	Mm
		729751 BTK_MOUSE (461-719): 7.15e-40: 159: 13.88		GRB2_MOUSE (1030-1085): 5.12e-13: 71.3: 33.33
+	Mm
		1141153 SH3K1_MOUSE (582-781): 3.29e-36: 148: 15.24		GRB2_MOUSE (1030-1085): 5.12e-13: 71.3: 33.33
+	Hs
		924520 ITK_HUMAN (509-735): 2.83e-33: 139: 10.82		GRB2_HUMAN (1030-1085): 4.24e-13: 71.7: 33.33
+	Hs
		802818 CRKL_HUMAN (583-731): 3.06e-34: 135: 19.08		GRB2_HUMAN (1030-1085): 4.24e-13: 71.7: 33.33
+	Hs
		557655 NCK1_HUMAN (605-851): 3.91e-26: 113: 12.06		GRB2_HUMAN (1030-1085): 4.24e-13: 71.7: 33.33