HitPredict

Interactor 1: CAND1 (G5ED41)
Cullin-associated NEDD8-dissociated protein 1 (Cullin-associated and neddylation-dissociated protein 1)
Gene: cand-1

Interactor 2: CUL2 (Q17390)
Cullin-2 (CUL-2)
Gene: cul-2

Species: Caenorhabditis elegans

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.64	1.00	0.800

Property	Details
Experiments	20659444, 17609115
Identification Methods	affinity chromatography technology, two hybrid, anti tag coimmunoprecipitation
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	Cullin~TIP120
Common GO terms	GO:0005634 - nucleus GO:0016567 - protein ubiquitination
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1274 Ce			1 791
+	Hs
		1041074 CAND1_HUMAN (2-1263): 0: 768: 36.00		CUL1_HUMAN (24-791): 0: 753: 31.68
+	Hs
		1041383 CAND1_HUMAN (2-1263): 0: 768: 36.00		CUL2_HUMAN (19-791): 0: 751: 42.78
+	Hs
		1043440 CAND1_HUMAN (2-1263): 0: 768: 36.00		CUL4B_HUMAN (2-791): 0: 749: 24.72
+	Mm
		1169688 CAND1_MOUSE (2-1263): 0: 764: 35.84		CUL1_MOUSE (24-791): 0: 752: 31.68
+	Hs
		1043084 CAND1_HUMAN (2-1263): 0: 768: 36.00		CUL4A_HUMAN (18-791): 0: 741: 23.92
+	Hs
		1041947 CAND1_HUMAN (2-1263): 0: 768: 36.00		CUL3_HUMAN (2-791): 0: 731: 24.06
+	Mm
		1169706 CAND2_MOUSE (3-1269): 0: 728: 32.53		CUL1_MOUSE (24-791): 0: 752: 31.68
+	Hs
		256748 CAND2_HUMAN (2-1269): 0: 720: 32.89		CUL1_HUMAN (24-791): 0: 753: 31.68
+	Ce
		105745 CAND1_CAEEL (1-1274): 0: 759: 100.00		CUL1_CAEEL (18-791): 0: 706: 27.61
+	Hs
		256749 CAND2_HUMAN (2-1269): 0: 720: 32.89		CUL3_HUMAN (2-791): 0: 731: 24.06
+	Ce
		105747 CAND1_CAEEL (1-1274): 0: 759: 100.00		CUL3_CAEEL (13-791): 0: 654: 23.88
+	Dm
		1213848 CAND1_DROME (4-1266): 0: 679: 34.93		Q8IP45_DROME (1-791): 0: 719: 24.19
+	Ce
		105749 CAND1_CAEEL (1-1274): 0: 759: 100.00		CUL6_CAEEL (26-791): 0: 623: 26.77
+	Dm
		1097204 CAND1_DROME (4-1266): 0: 679: 34.93		CUL1_DROME (24-791): 0: 703: 30.01
+	Hs
		1202033 CAND1_HUMAN (2-1263): 0: 768: 36.00		CUL5_HUMAN (25-791): 0: 602: 24.75
+	At
		1226075 CAND1_ARATH (1-1260): 0: 657: 29.67		CUL4_ARATH (3-791): 0: 693: 24.66
+	At
		1226078 CAND1_ARATH (1-1260): 0: 657: 29.67		CUL1_ARATH (21-791): 0: 691: 24.16
+	Ce
		105750 CAND1_CAEEL (1-1274): 0: 759: 100.00		CUL5_CAEEL (26-791): 0: 579: 24.60
+	Sp
		142920 CAND1_SCHPO (4-1263): 9.12e-112: 381: 19.20		CUL1_SCHPO (24-791): 0: 686: 30.15
+	Hs
		127264 IPO5_HUMAN (177-1224): 3.14e-49: 193: 9.87		CUL3_HUMAN (2-791): 0: 731: 24.06