HitPredict

Interactor 1: NCOA6 (Q14686)
Nuclear receptor coactivator 6 (Activating signal cointegrator 2) (ASC-2) (Amplified in breast cancer protein 3) (Cancer-amplified transcriptional coactivator ASC-2) (Nuclear receptor coactivator RAP250) (NRC RAP250) (Nuclear receptor-activating protein, 250 kDa) (Peroxisome proliferator-activated receptor-interacting protein) (PPAR-interacting protein) (PRIP) (Thyroid hormone receptor-binding protein)
Gene: NCOA6

Interactor 2: RBBP5 (Q15291)
Retinoblastoma-binding protein 5 (RBBP-5) (Retinoblastoma-binding protein RBQ-3)
Gene: RBBP5

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.95	0.60	0.758

Property	Details
Experiments	24981860, 33961781, 23508102, 17925232, 17500065, 23870121, 12482968, 19047629, 19433796, 17178841
Identification Methods	affinity chromatography technology, biochemical, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0006974 - DNA damage response GO:0035097 - histone methyltransferase complex GO:0044666 - MLL3/4 complex
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 2063 Hs			1 538
+	Hs
		1057782 NCOA6_HUMAN (1-2063): 0: 746: 100.00		FBXW7_HUMAN (279-521): 2.8e-16: 83.9: 10.56
+	Hs
		903229 NCOA6_HUMAN (1-2063): 0: 746: 100.00		WDR5_HUMAN (282-429): 2.1e-09: 61.2: 11.41
+	Hs
		1070796 CHD7_HUMAN (169-662): 2.63e-11: 71.8: 12.93		RBBP5_HUMAN (1-538): 2.69e-137: 410: 100.00
+	Mm
		99862 F6M2J9_MOUSE (339-1212): 9.08e-12: 72.9: 10.93		RBBP5_MOUSE (1-538): 9.56e-137: 408: 99.07
+	Hs
		1070746 KMT2C_HUMAN (535-1739): 1.33e-10: 69.2: 11.23		RBBP5_HUMAN (1-538): 2.69e-137: 410: 100.00
+	Hs
		1070759 MINT_HUMAN (1100-2062): 1.16e-09: 66.2: 9.24		RBBP5_HUMAN (1-538): 2.69e-137: 410: 100.00
+	Hs
		131738 BCL9_HUMAN (109-1440): 4.55e-36: 152: 9.92		SNR40_HUMAN (229-467): 1.49e-19: 92: 9.59
+	Hs
		1346974 NCOR2_HUMAN (296-2055): 1.78e-19: 98.3: 8.11		NLE1_HUMAN (2-135): 8.57e-34: 135: 18.38
+	Hs
		1302927 MINT_HUMAN (1100-2062): 1.16e-09: 66.2: 9.24		NLE1_HUMAN (2-135): 8.57e-34: 135: 18.38
+	Hs
		1288413 NCOR2_HUMAN (296-2055): 1.78e-19: 98.3: 8.11		SNR40_HUMAN (229-467): 1.49e-19: 92: 9.59
+	Hs
		1164188 NCOR2_HUMAN (296-2055): 1.78e-19: 98.3: 8.11		BRWD3_HUMAN (228-450): 4.8e-15: 80.8: 12.86
+	Hs
		1262850 NCOR2_HUMAN (296-2055): 1.78e-19: 98.3: 8.11		PHIP_HUMAN (227-374): 6.69e-15: 80.4: 13.91
+	Hs
		1244287 ARI1B_HUMAN (582-2022): 5.83e-14: 80.2: 10.54		SNR40_HUMAN (229-467): 1.49e-19: 92: 9.59
+	Hs
		1056932 MDC1_HUMAN (157-945): 1.46e-12: 75.8: 11.15		SNR40_HUMAN (229-467): 1.49e-19: 92: 9.59
+	Hs
		1056974 MDC1_HUMAN (157-945): 1.46e-12: 75.8: 11.15		WDR33_HUMAN (198-342): 2.09e-17: 88.1: 10.67
+	Hs
		1281391 PRR36_HUMAN (90-884): 2.2e-13: 78.3: 9.81		FBXW7_HUMAN (279-521): 2.8e-16: 83.9: 10.56
+	Hs
		297832 K0754_HUMAN (159-398): 1.31e-13: 79.3: 12.92		BRWD3_HUMAN (228-450): 4.8e-15: 80.8: 12.86
+	Hs
		1288258 MINT_HUMAN (1100-2062): 1.16e-09: 66.2: 9.24		SNR40_HUMAN (229-467): 1.49e-19: 92: 9.59
+	Hs
		820867 PRC2A_HUMAN (208-2062): 5.88e-16: 86.8: 7.66		WDR5_HUMAN (282-429): 2.1e-09: 61.2: 11.41
+	Hs
		903374 KMT2C_HUMAN (535-1739): 1.33e-10: 69.2: 11.23		WDR5_HUMAN (282-429): 2.1e-09: 61.2: 11.41