HitPredict

Interactor 1: NCOA6 (Q14686)
Nuclear receptor coactivator 6 (Activating signal cointegrator 2) (ASC-2) (Amplified in breast cancer protein 3) (Cancer-amplified transcriptional coactivator ASC-2) (Nuclear receptor coactivator RAP250) (NRC RAP250) (Nuclear receptor-activating protein, 250 kDa) (Peroxisome proliferator-activated receptor-interacting protein) (PPAR-interacting protein) (PRIP) (Thyroid hormone receptor-binding protein)
Gene: NCOA6

Interactor 2: NR1H4 (Q96RI1)
Bile acid receptor (Farnesoid X-activated receptor) (Farnesol receptor HRR-1) (Nuclear receptor subfamily 1 group H member 4) (Retinoid X receptor-interacting protein 14) (RXR-interacting protein 14)
Gene: NR1H4

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	0.60	0.501

Property	Details
Experiments	21330447
Identification Methods	pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005654 - nucleoplasm GO:0045893 - positive regulation of DNA-templated transcription GO:0045944 - positive regulation of transcription by RNA polymerase II GO:0046965 - nuclear retinoid X receptor binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 2063 Hs			1 486
+	Hs
		369612 NCOA6_HUMAN (1-2063): 0: 746: 100.00		ESR1_HUMAN (10-486): 3.86e-118: 360: 21.91
+	Hs
		587169 NCOA6_HUMAN (1-2063): 0: 746: 100.00		RXRA_HUMAN (11-485): 4.19e-119: 358: 20.78
+	Hs
		1025253 NCOA6_HUMAN (1-2063): 0: 746: 100.00		NR1H3_HUMAN (60-486): 1.64e-112: 341: 34.57
+	Hs
		874381 NCOA6_HUMAN (1-2063): 0: 746: 100.00		NR1H2_HUMAN (44-486): 5.33e-109: 332: 30.19
+	Hs
		487970 NCOA6_HUMAN (1-2063): 0: 746: 100.00		RARA_HUMAN (37-484): 3.76e-103: 317: 25.61
+	Hs
		740524 NCOA6_HUMAN (1-2063): 0: 746: 100.00		PPARG_HUMAN (48-483): 3.41e-102: 317: 26.32
+	Hs
		500485 NCOA6_HUMAN (1-2063): 0: 746: 100.00		THB_HUMAN (72-485): 1.08e-100: 311: 26.95
+	Hs
		782542 NCOA6_HUMAN (1-2063): 0: 746: 100.00		HNF4A_HUMAN (113-483): 6.35e-100: 309: 23.14
+	Hs
		1057780 NCOA6_HUMAN (1-2063): 0: 746: 100.00		ESR2_HUMAN (35-486): 2.01e-98: 307: 21.15
+	Hs
		500421 NCOA6_HUMAN (1-2063): 0: 746: 100.00		THA_HUMAN (134-444): 4.36e-41: 155: 33.43
+	Mm
		1111923 SMCA4_MOUSE (351-700): 1.27e-23: 112: 16.81		NR1H4_MOUSE (1-486): 5.66e-157: 456: 91.80
+	Hs
		370417 TARA_HUMAN (168-1726): 1.14e-25: 118: 9.69		ESR1_HUMAN (10-486): 3.86e-118: 360: 21.91
+	Hs
		368927 MUC1_HUMAN (159-883): 4.81e-23: 110: 10.47		ESR1_HUMAN (10-486): 3.86e-118: 360: 21.91
+	Hs
		370824 NCOR2_HUMAN (296-2055): 1.78e-19: 98.3: 8.11		ESR1_HUMAN (10-486): 3.86e-118: 360: 21.91
+	Mm
		1111929 SMCA4_MOUSE (351-700): 1.27e-23: 112: 16.81		ERR2_MOUSE (37-485): 5.61e-105: 321: 21.59
+	Hs
		554279 MUC1_HUMAN (159-883): 4.81e-23: 110: 10.47		PPARG_HUMAN (48-483): 3.41e-102: 317: 26.32
+	Hs
		1269591 TARA_HUMAN (168-1726): 1.14e-25: 118: 9.69		ESR2_HUMAN (35-486): 2.01e-98: 307: 21.15
+	Hs
		500380 NCOR2_HUMAN (296-2055): 1.78e-19: 98.3: 8.11		RARB_HUMAN (38-484): 9.82e-104: 319: 27.31
+	Hs
		554348 MUC1_HUMAN (159-883): 4.81e-23: 110: 10.47		ESR2_HUMAN (35-486): 2.01e-98: 307: 21.15
+	Hs
		488042 NCOR2_HUMAN (296-2055): 1.78e-19: 98.3: 8.11		RARA_HUMAN (37-484): 3.76e-103: 317: 25.61