HitPredict

Interactor 1: UBP10 (Q14694)
Ubiquitin carboxyl-terminal hydrolase 10 (EC 3.4.19.12) (Deubiquitinating enzyme 10) (Ubiquitin thioesterase 10) (Ubiquitin-specific-processing protease 10)
Gene: USP10

Interactor 2: NEMO (Q9Y6K9)
NF-kappa-B essential modulator (NEMO) (FIP-3) (IkB kinase-associated protein 1) (IKKAP1) (Inhibitor of nuclear factor kappa-B kinase subunit gamma) (I-kappa-B kinase subunit gamma) (IKK-gamma) (IKKG) (IkB kinase subunit gamma) (NF-kappa-B essential modifier)
Gene: IKBKG

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.68	0.60	0.639

Property	Details
Experiments	25861989, 24270572
Identification Methods	affinity chromatography technology, enzymatic study, anti bait coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0006974 - DNA damage response and 1 others more... GO:0032991 - protein-containing complex
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 798 Hs			1 419
+	Mm
		291784 UBP10_MOUSE (1-798): 0: 690: 83.23		NEMO_MOUSE (1-419): 3e-53: 184: 86.64
+	Hs
		1058272 UBP10_HUMAN (1-798): 0: 720: 100.00		OPTN_HUMAN (67-418): 2.78e-38: 147: 27.25
+	Hs
		271230 UBP2_HUMAN (161-793): 7.79e-111: 352: 16.82		NEMO_HUMAN (1-419): 1.12e-52: 183: 100.00
+	Hs
		271166 UBP2_HUMAN (161-793): 7.79e-111: 352: 16.82		OPTN_HUMAN (67-418): 2.78e-38: 147: 27.25
+	Hs
		271039 UBP2_HUMAN (161-793): 7.79e-111: 352: 16.82		MYH9_HUMAN (11-402): 4.5e-11: 67.3: 9.93
+	Dm
		1213448 Q9W0L7_DROME (320-798): 7.21e-106: 357: 37.58		Q8INC1_DROME (48-381): 2e-09: 61.9: 15.83
+	Hs
		551869 UBP22_HUMAN (374-795): 4.81e-87: 287: 19.17		DESP_HUMAN (45-363): 7.32e-21: 97.8: 15.84
+	Hs
		725051 UBP36_HUMAN (369-795): 4.36e-90: 309: 22.94		MYH9_HUMAN (11-402): 4.5e-11: 67.3: 9.93