HitPredict

Interactor 1: STAT4 (Q14765)
Signal transducer and activator of transcription 4
Gene: STAT4

Interactor 2: I12R2 (Q99665)
Interleukin-12 receptor subunit beta-2 (IL-12 receptor subunit beta-2) (IL-12R subunit beta-2) (IL-12R-beta-2) (IL-12RB2)
Gene: IL12RB2

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.64	1.00	0.806

Property	Details
Experiments	10415122, 9890938
Identification Methods	unspecified method, anti tag coimmunoprecipitation, pull down, fluorescence polarization spectroscopy
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	SH2~fn3, STAT_alpha~fn3
Common GO terms	GO:0019221 - cytokine-mediated signaling pathway GO:0035722 - interleukin-12-mediated signaling pathway
Homologous interactions	6

Homologous interactions

Color coding for hit scores

	1 748 Hs			1 862
+	Hs
		786373 STAT1_HUMAN (1-743): 0: 931: 52.65		I27RA_HUMAN (130-715): 5.5e-114: 363: 24.50
+	Hs
		770183 STAT1_HUMAN (1-743): 0: 931: 52.65		IL6RB_HUMAN (321-857): 1.25e-26: 118: 10.67
+	Hs
		770182 STAT3_HUMAN (1-728): 0: 882: 48.24		IL6RB_HUMAN (321-857): 1.25e-26: 118: 10.67
+	Hs
		234483 STAT3_HUMAN (1-728): 0: 882: 48.24		DSCAM_HUMAN (2-836): 6.26e-23: 107: 7.43
+	Hs
		776798 STAT3_HUMAN (1-728): 0: 882: 48.24		CSF3R_HUMAN (363-861): 2.46e-20: 98.9: 10.52
+	Mm
		786647 STA5A_MOUSE (1-724): 0: 746: 29.99		LEPR_MOUSE (129-316): 9.36e-12: 71: 16.91