HitPredict

Interactor 1: LTBP1 (Q14766)
Latent-transforming growth factor beta-binding protein 1 (LTBP-1) (Transforming growth factor beta-1-binding protein 1) (TGF-beta1-BP-1)
Gene: LTBP1

Interactor 2: FBLN5 (Q9UBX5)
Fibulin-5 (FIBL-5) (Developmental arteries and neural crest EGF-like protein) (Dance) (Urine p50 protein) (UP50)
Gene: FBLN5

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	1.00	0.691

Property	Details
Experiments	33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	EGF_CA~EGF_CA, EGF_CA~TB
Common GO terms	GO:0005509 - calcium ion binding GO:0005576 - extracellular region GO:0031012 - extracellular matrix GO:0062023 - collagen-containing extracellular matrix
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 1721 Hs			1 448
+	Hs
		1016949 LTBP1_HUMAN (1-1721): 0: 643: 100.00		FBLN3_HUMAN (3-214): 1.13e-14: 78: 22.62
+	Hs
		1059014 LTBP1_HUMAN (1-1721): 0: 643: 100.00		LTBP1_HUMAN (4-286): 1.43e-13: 75.2: 19.14
+	Hs
		957267 LTBP1_HUMAN (1-1721): 0: 643: 100.00		FBLN2_HUMAN (28-369): 2.11e-12: 71.4: 21.91
+	Hs
		980375 LTBP1_HUMAN (1-1721): 0: 643: 100.00		NOTC2_HUMAN (3-312): 4.71e-11: 67.2: 15.67
+	Hs
		724341 LTBP1_HUMAN (1-1721): 0: 643: 100.00		FBN1_HUMAN (27-367): 4.64e-09: 61: 17.71
+	Hs
		724370 LTBP1_HUMAN (1-1721): 0: 643: 100.00		FBN2_HUMAN (7-113): 5.15e-09: 60.9: 22.43
+	Hs
		1059111 LTBP2_HUMAN (24-1661): 7.22e-53: 207: 15.40		FBLN5_HUMAN (1-448): 1.31e-70: 232: 100.00
+	Hs
		980445 NOTC2_HUMAN (324-1440): 2.5e-70: 265: 14.04		LTBP4_HUMAN (9-286): 1.82e-19: 93.6: 24.32
+	Hs
		804213 NOTC2_HUMAN (324-1440): 2.5e-70: 265: 14.04		NOTC1_HUMAN (5-391): 1.25e-18: 91.1: 13.16
+	Dm
		422709 NOTCH_DROME (287-1427): 3.09e-70: 264: 13.21		NOTCH_DROME (3-343): 1.45e-14: 78.4: 12.89
+	Dm
		90684 NOTCH_DROME (287-1427): 3.09e-70: 264: 13.21		E1JHA6_DROME (103-446): 1.7e-09: 62.6: 11.56
+	Hs
		724367 NOTC2_HUMAN (324-1440): 2.5e-70: 265: 14.04		FBN2_HUMAN (7-113): 5.15e-09: 60.9: 22.43
+	Hs
		612843 NOTC2_HUMAN (324-1440): 2.5e-70: 265: 14.04		FBLN1_HUMAN (245-332): 8.14e-09: 59.8: 32.96
+	Hs
		1059076 LTBP2_HUMAN (24-1661): 7.22e-53: 207: 15.40		LTBP4_HUMAN (9-286): 1.82e-19: 93.6: 24.32
+	Hs
		724371 LTBP2_HUMAN (24-1661): 7.22e-53: 207: 15.40		FBN2_HUMAN (7-113): 5.15e-09: 60.9: 22.43
+	Hs
		1016997 LTBP3_HUMAN (943-1717): 1.24e-30: 134: 17.28		FBLN3_HUMAN (3-214): 1.13e-14: 78: 22.62
+	Hs
		724347 LTBP4_HUMAN (200-1289): 3.76e-28: 126: 12.71		FBN1_HUMAN (27-367): 4.64e-09: 61: 17.71
+	Hs
		612884 LTBP4_HUMAN (200-1289): 3.76e-28: 126: 12.71		FBLN1_HUMAN (245-332): 8.14e-09: 59.8: 32.96