HitPredict

Interactor 1: CBX2 (Q14781)
Chromobox protein homolog 2
Gene: CBX2

Interactor 2: H32 (Q71DI3)
Histone H3.2 (H3-clustered histone 13) (H3-clustered histone 14) (H3-clustered histone 15) (Histone H3/m) (Histone H3/o)
Gene: H3C15

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.53	0.60	0.568

Property	Details
Experiments	18927235
Identification Methods	protein complementation assay, affinity chromatography technology, bimolecular fluorescence complementation
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003677 - DNA binding GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0006325 - chromatin organization
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 532 Hs			1 136
+	Hs
		934768 CBX2_HUMAN (1-532): 6.32e-156: 457: 100.00		H31_HUMAN (1-136): 1.98e-62: 189: 99.27
+	Hs
		1059154 CBX2_HUMAN (1-532): 6.32e-156: 457: 100.00		H31T_HUMAN (1-136): 8.3e-62: 187: 96.32
+	Hs
		952341 CBX2_HUMAN (1-532): 6.32e-156: 457: 100.00		H33_HUMAN (1-136): 1.59e-61: 186: 97.06
+	Mm
		675496 CBX2_MOUSE (1-532): 1.26e-145: 430: 81.84		H33_MOUSE (1-136): 1.59e-61: 186: 97.06
+	Hs
		828230 CBX2_HUMAN (1-532): 6.32e-156: 457: 100.00		CENPA_HUMAN (9-133): 2.85e-44: 143: 50.00
+	Mm
		223226 CBX4_MOUSE (3-522): 1.1e-116: 357: 22.28		H33_MOUSE (1-136): 1.59e-61: 186: 97.06
+	Hs
		123231 CBX4_HUMAN (3-522): 6.17e-110: 340: 21.89		H31_HUMAN (1-136): 1.98e-62: 189: 99.27
+	Hs
		123254 CBX4_HUMAN (3-522): 6.17e-110: 340: 21.89		H31T_HUMAN (1-136): 8.3e-62: 187: 96.32
+	Hs
		123236 CBX4_HUMAN (3-522): 6.17e-110: 340: 21.89		H33_HUMAN (1-136): 1.59e-61: 186: 97.06
+	Hs
		123269 CBX4_HUMAN (3-522): 6.17e-110: 340: 21.89		H32_HUMAN (1-136): 3.73e-61: 186: 100.00
+	Hs
		111555 CBX4_HUMAN (3-522): 6.17e-110: 340: 21.89		K7EK07_HUMAN (1-132): 1.39e-59: 181: 96.97
+	Hs
		935387 CDYL_HUMAN (2-297): 1.28e-60: 211: 21.63		H31_HUMAN (1-136): 1.98e-62: 189: 99.27
+	Hs
		1086356 CDYL_HUMAN (2-297): 1.28e-60: 211: 21.63		H31T_HUMAN (1-136): 8.3e-62: 187: 96.32
+	Hs
		952709 CDYL_HUMAN (2-297): 1.28e-60: 211: 21.63		H33_HUMAN (1-136): 1.59e-61: 186: 97.06
+	Hs
		935156 MPP8_HUMAN (7-397): 6.88e-47: 177: 17.54		H31_HUMAN (1-136): 1.98e-62: 189: 99.27
+	Dm
		356104 Q9VCU6_DROME (9-253): 3.96e-52: 179: 20.64		H3_DROME (1-136): 3.73e-61: 186: 100.00
+	Hs
		934987 CDYL2_HUMAN (10-297): 9.15e-48: 175: 17.81		H31_HUMAN (1-136): 1.98e-62: 189: 99.27
+	Hs
		952579 MPP8_HUMAN (7-397): 6.88e-47: 177: 17.54		H33_HUMAN (1-136): 1.59e-61: 186: 97.06
+	Hs
		1086221 CDYL2_HUMAN (10-297): 9.15e-48: 175: 17.81		H31T_HUMAN (1-136): 8.3e-62: 187: 96.32
+	Dm
		356085 RHINO_DROME (1-315): 3.1e-47: 171: 16.35		H3_DROME (1-136): 3.73e-61: 186: 100.00