HitPredict

Interactor 1: CBX2 (Q14781)
Chromobox protein homolog 2
Gene: CBX2

Interactor 2: PHC3 (Q8NDX5)
Polyhomeotic-like protein 3 (Early development regulatory protein 3) (Homolog of polyhomeotic 3) (hPH3)
Gene: PHC3

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.78	0.60	0.686

Property	Details
Experiments	27705803, 22325352, 24981860, 37014752
Identification Methods	affinity chromatography technology, tandem affinity purification
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003677 - DNA binding GO:0003682 - chromatin binding GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0031519 - PcG protein complex and 1 others more... GO:0035102 - PRC1 complex
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 532 Hs			1 983
+	Mm
		675500 CBX2_MOUSE (1-532): 1.26e-145: 430: 81.84		PHC3_MOUSE (30-983): 1.26e-78: 278: 93.61
+	Hs
		123290 CBX4_HUMAN (3-522): 6.17e-110: 340: 21.89		PHC3_HUMAN (1-983): 3.72e-88: 305: 100.00
+	Hs
		1059182 CBX2_HUMAN (1-532): 6.32e-156: 457: 100.00		SCMH1_HUMAN (552-982): 1.15e-38: 155: 17.83
+	Hs
		943062 CBX2_HUMAN (1-532): 6.32e-156: 457: 100.00		PHC1_HUMAN (33-983): 9.51e-36: 148: 23.90
+	Hs
		1059204 CBX2_HUMAN (1-532): 6.32e-156: 457: 100.00		SCML2_HUMAN (553-982): 5.47e-34: 141: 17.40
+	Hs
		1059202 CBX2_HUMAN (1-532): 6.32e-156: 457: 100.00		SCML1_HUMAN (799-982): 6.24e-33: 132: 22.28
+	Mm
		675498 CBX2_MOUSE (1-532): 1.26e-145: 430: 81.84		PHC1_MOUSE (33-983): 3.74e-35: 147: 24.25
+	Hs
		1056829 CBX2_HUMAN (1-532): 6.32e-156: 457: 100.00		MDC1_HUMAN (38-926): 2.52e-24: 112: 9.32
+	Hs
		1059170 CBX2_HUMAN (1-532): 6.32e-156: 457: 100.00		PHC2_HUMAN (30-566): 3.66e-17: 88.9: 27.02
+	Hs
		123303 CBX4_HUMAN (3-522): 6.17e-110: 340: 21.89		SCMH1_HUMAN (552-982): 1.15e-38: 155: 17.83
+	Hs
		123234 CBX4_HUMAN (3-522): 6.17e-110: 340: 21.89		PHC1_HUMAN (33-983): 9.51e-36: 148: 23.90
+	Hs
		123346 CBX4_HUMAN (3-522): 6.17e-110: 340: 21.89		SCML2_HUMAN (553-982): 5.47e-34: 141: 17.40
+	Hs
		123342 CBX4_HUMAN (3-522): 6.17e-110: 340: 21.89		SCML1_HUMAN (799-982): 6.24e-33: 132: 22.28
+	Hs
		316103 CBX6_HUMAN (3-242): 2.28e-36: 141: 30.29		PHC3_HUMAN (1-983): 3.72e-88: 305: 100.00
+	Dr
		1193375 Q804D1_DANRE (3-521): 3.29e-99: 310: 24.04		PHC2_DANRE (172-983): 1.93e-30: 131: 23.58
+	Hs
		123280 CBX4_HUMAN (3-522): 6.17e-110: 340: 21.89		PHC2_HUMAN (30-566): 3.66e-17: 88.9: 27.02
+	Hs
		316124 CBX6_HUMAN (3-242): 2.28e-36: 141: 30.29		SCMH1_HUMAN (552-982): 1.15e-38: 155: 17.83
+	Hs
		316005 CBX6_HUMAN (3-242): 2.28e-36: 141: 30.29		PHC1_HUMAN (33-983): 9.51e-36: 148: 23.90
+	Hs
		316200 CBX6_HUMAN (3-242): 2.28e-36: 141: 30.29		SCML1_HUMAN (799-982): 6.24e-33: 132: 22.28
+	Hs
		316088 CBX6_HUMAN (3-242): 2.28e-36: 141: 30.29		PHC2_HUMAN (30-566): 3.66e-17: 88.9: 27.02