HitPredict

Interactor 1: CASP8 (Q14790)
Caspase-8 (CASP-8) (EC 3.4.22.61) (Apoptotic cysteine protease) (Apoptotic protease Mch-5) (CAP4) (FADD-homologous ICE/ced-3-like protease) (FADD-like ICE) (FLICE) (ICE-like apoptotic protease 5) (MORT1-associated ced-3 homolog) (MACH) [Cleaved into: Caspase-8 subunit p18; Caspase-8 subunit p10]
Gene: CASP8

Interactor 2: CASPA (Q92851)
Caspase-10 (CASP-10) (EC 3.4.22.63) (Apoptotic protease Mch-4) (FAS-associated death domain protein interleukin-1B-converting enzyme 2) (FLICE2) (ICE-like apoptotic protease 4) [Cleaved into: Caspase-10 subunit p23/17; Caspase-10 subunit p12]
Gene: CASP10

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.94 1.00 0.974

The method score is based on:

Property Details
Experiments 15659383, 12887920, 8962078, 21737330, 11832478, 34839354, 15280356, 22864571, 22421964, 11717445, 17159907
Identification Methods biochemical, affinity chromatography technology, enzymatic study, anti tag coimmunoprecipitation, fluorescent resonance energy transfer, anti bait coimmunoprecipitation
Interaction Type association, physical association, direct interaction

The annotation score is based on:

Property Details
Interacting Pfam domains DED~DED, Peptidase_C14~Peptidase_C14
Common GO terms GO:0004197 - cysteine-type endopeptidase activity
GO:0005737 - cytoplasm
GO:0005829 - cytosol
GO:0006508 - proteolysis
GO:0006915 - apoptotic process
and 11 others

more...
Homologous interactions 17

Homologous interactions

Color coding for hit scores

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Hs

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Last updated: 15 Jul 2024