HitPredict

Interactor 1: CHD4 (Q14839)
Chromodomain-helicase-DNA-binding protein 4 (CHD-4) (EC 3.6.4.12) (ATP-dependent helicase CHD4) (Mi-2 autoantigen 218 kDa protein) (Mi2-beta)
Gene: CHD4

Interactor 2: NUMA1 (Q14980)
Nuclear mitotic apparatus protein 1 (Nuclear matrix protein-22) (NMP-22) (Nuclear mitotic apparatus protein) (NuMA protein) (SP-H antigen)
Gene: NUMA1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.71	0.60	0.656

Property	Details
Experiments	28977666, 32744500, 35271311
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005813 - centrosome GO:0032991 - protein-containing complex
Homologous interactions	9

Homologous interactions

Color coding for hit scores

	1 1912 Hs			1 2115
+	Hs
		1018486 CHD3_HUMAN (23-1905): 0: 1595: 66.89		NUMA1_HUMAN (1-2115): 1.36e-162: 555: 100.00
+	Hs
		724833 CHD4_HUMAN (1-1912): 0: 1719: 100.00		MYH9_HUMAN (1033-1891): 1.22e-33: 145: 10.62
+	Hs
		725163 CHD4_HUMAN (1-1912): 0: 1719: 100.00		MYH10_HUMAN (1281-2075): 5.26e-33: 142: 12.34
+	Hs
		518869 CHD4_HUMAN (1-1912): 0: 1719: 100.00		TPR_HUMAN (2-620): 2.42e-18: 94.7: 12.04
+	Hs
		724799 CHD3_HUMAN (23-1905): 0: 1595: 66.89		MYH9_HUMAN (1033-1891): 1.22e-33: 145: 10.62
+	Hs
		725150 CHD3_HUMAN (23-1905): 0: 1595: 66.89		MYH10_HUMAN (1281-2075): 5.26e-33: 142: 12.34
+	Hs
		229401 SMCA5_HUMAN (578-1624): 0: 791: 26.01		NUMA1_HUMAN (1-2115): 1.36e-162: 555: 100.00
+	Hs
		658673 SMCA1_HUMAN (617-1597): 0: 779: 27.44		NUMA1_HUMAN (1-2115): 1.36e-162: 555: 100.00
+	Hs
		658678 SMCA1_HUMAN (617-1597): 0: 779: 27.44		EEA1_HUMAN (964-1838): 2.18e-28: 127: 12.15