HitPredict

Interactor 1: CHD4 (Q14839)
Chromodomain-helicase-DNA-binding protein 4 (CHD-4) (EC 3.6.4.12) (ATP-dependent helicase CHD4) (Mi-2 autoantigen 218 kDa protein) (Mi2-beta)
Gene: CHD4

Interactor 2: H2B1H (Q93079)
Histone H2B type 1-H (H2B-clustered histone 9) (Histone H2B.j) (H2B/j)
Gene: H2BC9

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.60	1.00	0.776

Property	Details
Experiments	28977666, 30021884
Identification Methods	affinity chromatography technology, proximity labelling technology, cross-linking study
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Histone~SNF2-rel_dom
Common GO terms	GO:0003677 - DNA binding GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0032991 - protein-containing complex
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1912 Hs			1 126
+	Hs
		1059648 CHD4_HUMAN (1-1912): 0: 1719: 100.00		H2B2E_HUMAN (1-126): 5.74e-55: 169: 98.41
+	Hs
		241527 CHD4_HUMAN (1-1912): 0: 1719: 100.00		H2B1K_HUMAN (1-126): 1.18e-54: 168: 98.41
+	Hs
		707635 CHD4_HUMAN (1-1912): 0: 1719: 100.00		H2B1B_HUMAN (1-126): 1.44e-54: 168: 96.83
+	Hs
		918368 CHD4_HUMAN (1-1912): 0: 1719: 100.00		H2B1C_HUMAN (1-126): 1.07e-54: 168: 99.21
+	Hs
		886109 CHD4_HUMAN (1-1912): 0: 1719: 100.00		H2B1D_HUMAN (1-126): 3.03e-54: 167: 98.41
+	Hs
		1059827 CHD4_HUMAN (1-1912): 0: 1719: 100.00		H2B1L_HUMAN (1-126): 2.43e-53: 165: 97.62
+	Hs
		1059782 CHD4_HUMAN (1-1912): 0: 1719: 100.00		H2B1A_HUMAN (1-126): 1.15e-47: 151: 84.25
+	Hs
		1018625 CHD3_HUMAN (23-1905): 0: 1595: 66.89		H2B1H_HUMAN (1-126): 4.31e-55: 169: 100.00
+	Hs
		241517 CHD3_HUMAN (23-1905): 0: 1595: 66.89		H2B1K_HUMAN (1-126): 1.18e-54: 168: 98.41
+	Hs
		707612 CHD3_HUMAN (23-1905): 0: 1595: 66.89		H2B1B_HUMAN (1-126): 1.44e-54: 168: 96.83
+	Hs
		918325 CHD3_HUMAN (23-1905): 0: 1595: 66.89		H2B1C_HUMAN (1-126): 1.07e-54: 168: 99.21
+	Hs
		241591 CHD5_HUMAN (86-1909): 0: 1584: 71.18		H2B1K_HUMAN (1-126): 1.18e-54: 168: 98.41
+	Hs
		918541 CHD5_HUMAN (86-1909): 0: 1584: 71.18		H2B1C_HUMAN (1-126): 1.07e-54: 168: 99.21
+	Hs
		1087449 CHD7_HUMAN (3-1678): 0: 805: 23.02		H2B2E_HUMAN (1-126): 5.74e-55: 169: 98.41
+	Hs
		707773 CHD7_HUMAN (3-1678): 0: 805: 23.02		H2B1B_HUMAN (1-126): 1.44e-54: 168: 96.83
+	Hs
		918744 CHD7_HUMAN (3-1678): 0: 805: 23.02		H2B1C_HUMAN (1-126): 1.07e-54: 168: 99.21
+	Sp
		144534 HRP3_SCHPO (535-1673): 0: 816: 28.33		H2B1_SCHPO (4-125): 6.05e-46: 146: 70.49
+	Hs
		229415 SMCA5_HUMAN (578-1624): 0: 791: 26.01		H2B2E_HUMAN (1-126): 5.74e-55: 169: 98.41
+	Hs
		229321 SMCA5_HUMAN (578-1624): 0: 791: 26.01		H2B1B_HUMAN (1-126): 1.44e-54: 168: 96.83
+	Hs
		229353 SMCA5_HUMAN (578-1624): 0: 791: 26.01		H2B1C_HUMAN (1-126): 1.07e-54: 168: 99.21