HitPredict

Interactor 1: CHD4 (Q14839)
Chromodomain-helicase-DNA-binding protein 4 (CHD-4) (EC 3.6.4.12) (ATP-dependent helicase CHD4) (Mi-2 autoantigen 218 kDa protein) (Mi2-beta)
Gene: CHD4

Interactor 2: NACC2 (Q96BF6)
Nucleus accumbens-associated protein 2 (NAC-2) (BTB/POZ domain-containing protein 14A) (Repressor with BTB domain and BEN domain)
Gene: NACC2

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	22926524
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0000785 - chromatin GO:0005634 - nucleus GO:0042826 - histone deacetylase binding GO:0045892 - negative regulation of DNA-templated transcription
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 1912 Hs			1 587
+	Hs
		312067 CHD4_HUMAN (1-1912): 0: 1719: 100.00		ZBT7A_HUMAN (2-482): 7.25e-61: 213: 14.98
+	Hs
		166168 CHD4_HUMAN (1-1912): 0: 1719: 100.00		ZBTB5_HUMAN (7-310): 6.63e-50: 185: 19.38
+	Hs
		1059889 CHD4_HUMAN (1-1912): 0: 1719: 100.00		MYNN_HUMAN (99-496): 9.72e-40: 155: 9.54
+	Hs
		1059638 CHD4_HUMAN (1-1912): 0: 1719: 100.00		ZKSC8_HUMAN (113-360): 5.59e-32: 132: 7.12
+	Hs
		312061 CHD3_HUMAN (23-1905): 0: 1595: 66.89		ZBT7A_HUMAN (2-482): 7.25e-61: 213: 14.98
+	Hs
		1059709 CHD4_HUMAN (1-1912): 0: 1719: 100.00		ZBT46_HUMAN (137-371): 2.86e-12: 71.4: 10.71
+	Hs
		166165 CHD3_HUMAN (23-1905): 0: 1595: 66.89		ZBTB5_HUMAN (7-310): 6.63e-50: 185: 19.38
+	Hs
		781352 CHD3_HUMAN (23-1905): 0: 1595: 66.89		BCL6_HUMAN (6-323): 9.06e-44: 168: 21.71
+	Mm
		1145176 CHD4_MOUSE (1-1900): 0: 1680: 97.80		ZBT7B_MOUSE (249-353): 1.56e-14: 78.5: 8.49
+	Hs
		1018504 CHD3_HUMAN (23-1905): 0: 1595: 66.89		ZKSC8_HUMAN (113-360): 5.59e-32: 132: 7.12
+	Hs
		229263 SMCA5_HUMAN (578-1624): 0: 791: 26.01		ZBT7A_HUMAN (2-482): 7.25e-61: 213: 14.98
+	Hs
		229527 SMCA5_HUMAN (578-1624): 0: 791: 26.01		KLH20_HUMAN (4-259): 1.27e-53: 194: 13.97
+	Hs
		658752 SMCA1_HUMAN (617-1597): 0: 779: 27.44		KLH20_HUMAN (4-259): 1.27e-53: 194: 13.97
+	Hs
		312092 CHD8_HUMAN (489-1678): 0: 752: 28.31		ZBT7A_HUMAN (2-482): 7.25e-61: 213: 14.98
+	Mm
		57196 CHD7_MOUSE (3-1678): 0: 817: 23.03		Q9QZF3_MOUSE (1-283): 2.55e-36: 146: 25.51
+	Hs
		1335865 CHD7_HUMAN (3-1678): 0: 805: 23.02		ZBT20_HUMAN (1-283): 1.73e-36: 147: 25.51
+	Hs
		157246 CHD8_HUMAN (489-1678): 0: 752: 28.31		BACH1_HUMAN (3-132): 2.13e-35: 143: 32.33
+	Mm
		1145258 SMCA5_MOUSE (601-1624): 0: 795: 26.39		ZBT7B_MOUSE (249-353): 1.56e-14: 78.5: 8.49