HitPredict

Interactor 1: CHD4 (Q14839)
Chromodomain-helicase-DNA-binding protein 4 (CHD-4) (EC 3.6.4.12) (ATP-dependent helicase CHD4) (Mi-2 autoantigen 218 kDa protein) (Mi2-beta)
Gene: CHD4

Interactor 2: HELLS (Q9NRZ9)
Lymphoid-specific helicase (EC 3.6.4.-) (Proliferation-associated SNF2-like protein) (SWI/SNF2-related matrix-associated actin-dependent regulator of chromatin subfamily A member 6)
Gene: HELLS

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	28977666
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Chromo~SNF2-rel_dom, Helicase_C~Helicase_C, Helicase_C~SNF2-rel_dom, SNF2-rel_dom~SNF2-rel_dom
Common GO terms	GO:0003682 - chromatin binding GO:0004386 - helicase activity GO:0005524 - ATP binding GO:0005634 - nucleus GO:0140658 - ATP-dependent chromatin remodeler activity
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 1912 Hs			1 838
+	Hs
		1018483 CHD4_HUMAN (1-1912): 0: 1719: 100.00		CHD3_HUMAN (50-828): 0: 649: 24.79
+	Hs
		846970 CHD4_HUMAN (1-1912): 0: 1719: 100.00		SMCA4_HUMAN (9-838): 0: 633: 24.89
+	Hs
		1059614 CHD4_HUMAN (1-1912): 0: 1719: 100.00		CHD4_HUMAN (51-828): 0: 630: 25.39
+	Hs
		1059751 CHD4_HUMAN (1-1912): 0: 1719: 100.00		CHD5_HUMAN (50-835): 0: 627: 24.83
+	Hs
		229399 CHD4_HUMAN (1-1912): 0: 1719: 100.00		SMCA5_HUMAN (75-833): 0: 607: 30.76
+	Hs
		658672 CHD4_HUMAN (1-1912): 0: 1719: 100.00		SMCA1_HUMAN (104-833): 0: 596: 31.06
+	Hs
		846775 CHD4_HUMAN (1-1912): 0: 1719: 100.00		SMCA2_HUMAN (27-838): 0: 584: 26.37
+	Hs
		1018442 CHD3_HUMAN (23-1905): 0: 1595: 66.89		CHD3_HUMAN (50-828): 0: 649: 24.79
+	Hs
		846950 CHD3_HUMAN (23-1905): 0: 1595: 66.89		SMCA4_HUMAN (9-838): 0: 633: 24.89
+	Hs
		1018602 CHD3_HUMAN (23-1905): 0: 1595: 66.89		CHD5_HUMAN (50-835): 0: 627: 24.83
+	Hs
		229379 CHD3_HUMAN (23-1905): 0: 1595: 66.89		SMCA5_HUMAN (75-833): 0: 607: 30.76
+	Hs
		658660 CHD3_HUMAN (23-1905): 0: 1595: 66.89		SMCA1_HUMAN (104-833): 0: 596: 31.06
+	Hs
		846763 CHD3_HUMAN (23-1905): 0: 1595: 66.89		SMCA2_HUMAN (27-838): 0: 584: 26.37
+	Hs
		1059873 CHD4_HUMAN (1-1912): 0: 1719: 100.00		SMRCD_HUMAN (206-744): 1.53e-92: 315: 37.59
+	Dm
		332724 CHDM_DROME (1-1904): 0: 1364: 50.85		CHDM_DROME (41-829): 0: 596: 25.20
+	Mm
		57185 CHD7_MOUSE (3-1678): 0: 817: 23.03		SMCA4_MOUSE (9-838): 0: 636: 25.42
+	Sp
		144540 HRP3_SCHPO (535-1673): 0: 816: 28.33		HRP1_SCHPO (51-832): 0: 597: 29.00