HitPredict

Interactor 1: CHD4 (Q14839)
Chromodomain-helicase-DNA-binding protein 4 (CHD-4) (EC 3.6.4.12) (ATP-dependent helicase CHD4) (Mi-2 autoantigen 218 kDa protein) (Mi2-beta)
Gene: CHD4

Interactor 2: H2AW (Q9P0M6)
Core histone macro-H2A.2 (Histone macroH2A2) (mH2A2)
Gene: MACROH2A2

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	32744500
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Histone~SNF2-rel_dom
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0000781 - chromosome, telomeric region GO:0000785 - chromatin GO:0005634 - nucleus GO:0005654 - nucleoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1912 Hs			1 372
+	Hs
		260883 CHD4_HUMAN (1-1912): 0: 1719: 100.00		H2AY_HUMAN (1-371): 8.19e-156: 444: 66.31
+	Hs
		555466 CHD4_HUMAN (1-1912): 0: 1719: 100.00		H2AX_HUMAN (1-144): 1.72e-66: 208: 57.14
+	Hs
		1059717 CHD4_HUMAN (1-1912): 0: 1719: 100.00		H2A2B_HUMAN (1-123): 1.24e-64: 203: 63.49
+	Hs
		1059647 CHD4_HUMAN (1-1912): 0: 1719: 100.00		H2A2C_HUMAN (1-126): 7.57e-64: 201: 61.24
+	Hs
		1059795 CHD4_HUMAN (1-1912): 0: 1719: 100.00		H2A1H_HUMAN (1-125): 5.02e-64: 201: 60.94
+	Hs
		391704 CHD4_HUMAN (1-1912): 0: 1719: 100.00		H2A1B_HUMAN (1-126): 6.65e-64: 201: 60.47
+	Hs
		470387 CHD4_HUMAN (1-1912): 0: 1719: 100.00		H2A1_HUMAN (1-126): 6.37e-64: 201: 60.47
+	Hs
		1018640 CHD3_HUMAN (23-1905): 0: 1595: 66.89		H2A1H_HUMAN (1-125): 5.02e-64: 201: 60.94
+	Hs
		391675 CHD3_HUMAN (23-1905): 0: 1595: 66.89		H2A1B_HUMAN (1-126): 6.65e-64: 201: 60.47
+	Dm
		332757 CHDM_DROME (1-1904): 0: 1364: 50.85		H2A_DROME (14-122): 3.54e-63: 199: 67.89
+	Hs
		229254 SMCA5_HUMAN (578-1624): 0: 791: 26.01		H2AY_HUMAN (1-371): 8.19e-156: 444: 66.31
+	Hs
		260763 SMCA1_HUMAN (617-1597): 0: 779: 27.44		H2AY_HUMAN (1-371): 8.19e-156: 444: 66.31
+	Hs
		229296 SMCA5_HUMAN (578-1624): 0: 791: 26.01		H2AX_HUMAN (1-144): 1.72e-66: 208: 57.14
+	Hs
		229433 SMCA5_HUMAN (578-1624): 0: 791: 26.01		H2A2B_HUMAN (1-123): 1.24e-64: 203: 63.49
+	Hs
		229279 SMCA5_HUMAN (578-1624): 0: 791: 26.01		H2A1B_HUMAN (1-126): 6.65e-64: 201: 60.47
+	Hs
		555306 SMCA1_HUMAN (617-1597): 0: 779: 27.44		H2AX_HUMAN (1-144): 1.72e-66: 208: 57.14
+	Hs
		391728 CHD9_HUMAN (111-1653): 0: 783: 22.99		H2A1B_HUMAN (1-126): 6.65e-64: 201: 60.47
+	Hs
		470278 SMCA1_HUMAN (617-1597): 0: 779: 27.44		H2A1_HUMAN (1-126): 6.37e-64: 201: 60.47
+	Sp
		144532 HRP3_SCHPO (535-1673): 0: 816: 28.33		H2A1_SCHPO (3-123): 1.71e-40: 141: 63.71
+	Sp
		144533 HRP3_SCHPO (535-1673): 0: 816: 28.33		H2A2_SCHPO (3-123): 1.24e-39: 139: 64.52