HitPredict

Interactor 1: LASP1 (Q14847)
LIM and SH3 domain protein 1 (LASP-1) (Metastatic lymph node gene 50 protein) (MLN 50)
Gene: LASP1

Interactor 2: ZYX (Q15942)
Zyxin (Zyxin-2)
Gene: ZYX

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.69	1.00	0.836

Property	Details
Experiments	15004028, 34079125, 22665060
Identification Methods	two hybrid, pull down, proximity labelling technology
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	LIM~LIM
Common GO terms	GO:0005737 - cytoplasm GO:0005925 - focal adhesion GO:0046872 - metal ion binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 261 Hs			1 572
+	Mm
		1143127 LASP1_MOUSE (1-261): 2.2e-56: 183: 95.06		ZYX_MOUSE (1-572): 3.2e-62: 216: 85.02
+	Hs
		282335 NEBL_HUMAN (36-261): 8.63e-29: 116: 31.67		ZYX_HUMAN (1-572): 1.68e-71: 241: 100.00
+	Hs
		1049708 ARHG7_HUMAN (43-261): 1.37e-25: 107: 14.16		ZYX_HUMAN (1-572): 1.68e-71: 241: 100.00
+	Hs
		1080682 SH319_HUMAN (189-261): 2.12e-13: 71.4: 35.62		ZYX_HUMAN (1-572): 1.68e-71: 241: 100.00
+	Hs
		1080768 SRBS1_HUMAN (149-259): 7.54e-13: 69.9: 31.30		ZYX_HUMAN (1-572): 1.68e-71: 241: 100.00
+	Hs
		1060077 LASP1_HUMAN (1-261): 1.82e-58: 188: 100.00		TES_HUMAN (345-499): 3.83e-20: 95.1: 17.28
+	Hs
		238961 ARHG7_HUMAN (43-261): 1.37e-25: 107: 14.16		LPXN_HUMAN (221-570): 4.84e-47: 170: 18.75
+	Hs
		1060028 LASP1_HUMAN (1-261): 1.82e-58: 188: 100.00		LPP_HUMAN (4-495): 1.9e-13: 75.1: 13.92
+	Mm
		1143132 LASP1_MOUSE (1-261): 2.2e-56: 183: 95.06		LPP_MOUSE (4-495): 2.47e-12: 71.6: 15.71
+	Hs
		1044592 LASP1_HUMAN (1-261): 1.82e-58: 188: 100.00		FHL3_HUMAN (410-544): 1.63e-09: 61.2: 28.99
+	Hs
		823391 ARHG7_HUMAN (43-261): 1.37e-25: 107: 14.16		PAXI_HUMAN (8-500): 3.72e-32: 132: 12.12
+	Hs
		823393 SRC8_HUMAN (38-260): 4.28e-23: 99: 17.62		PAXI_HUMAN (8-500): 3.72e-32: 132: 12.12
+	Hs
		823484 SRBS1_HUMAN (149-259): 7.54e-13: 69.9: 31.30		PAXI_HUMAN (8-500): 3.72e-32: 132: 12.12
+	Hs
		1355075 DBNL_HUMAN (59-261): 2.02e-25: 105: 23.65		TES_HUMAN (345-499): 3.83e-20: 95.1: 17.28
+	Hs
		1052344 SRC8_HUMAN (38-260): 4.28e-23: 99: 17.62		TES_HUMAN (345-499): 3.83e-20: 95.1: 17.28
+	Hs
		596196 NEBU_HUMAN (15-261): 2.62e-29: 118: 29.11		LIMS1_HUMAN (383-566): 1.09e-10: 65.1: 25.95
+	Mm
		250825 PLCG2_MOUSE (17-261): 7.01e-22: 96.9: 13.88		FHL2_MOUSE (468-572): 1.05e-17: 85.4: 24.76
+	Hs
		282330 NEBL_HUMAN (36-261): 8.63e-29: 116: 31.67		FHL3_HUMAN (410-544): 1.63e-09: 61.2: 28.99
+	Hs
		1044619 CRIP3_HUMAN (5-55): 7.06e-15: 73.4: 37.26		FHL3_HUMAN (410-544): 1.63e-09: 61.2: 28.99
+	Hs
		816232 CSRP3_HUMAN (4-59): 3.22e-12: 65.6: 33.93		LIMS1_HUMAN (383-566): 1.09e-10: 65.1: 25.95