HitPredict

Interactor 1: NOLC1 (Q14978)
Nucleolar and coiled-body phosphoprotein 1 (140 kDa nucleolar phosphoprotein) (Nopp140) (Hepatitis C virus NS5A-transactivated protein 13) (HCV NS5A-transactivated protein 13) (Nucleolar 130 kDa protein) (Nucleolar phosphoprotein p130)
Gene: NOLC1

Interactor 2: ESR2 (Q92731)
Estrogen receptor beta (ER-beta) (Nuclear receptor subfamily 3 group A member 2)
Gene: ESR2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.54	0.60	0.571

Property	Details
Experiments	29509190, 21182203
Identification Methods	affinity chromatography technology, cosedimentation through density gradient
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005654 - nucleoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 699 Hs			1 530
+	Hs
		369444 TOP2B_HUMAN (6-463): 1.53e-66: 241: 14.13		ESR1_HUMAN (9-529): 3.58e-138: 413: 44.56
+	Hs
		368882 TOP2A_HUMAN (6-372): 1.49e-41: 165: 14.44		ESR1_HUMAN (9-529): 3.58e-138: 413: 44.56
+	Hs
		487950 TOP2B_HUMAN (6-463): 1.53e-66: 241: 14.13		RARA_HUMAN (52-505): 3.54e-105: 324: 23.74
+	Hs
		1270066 PCLO_HUMAN (139-681): 1.17e-18: 93.5: 9.27		ESR2_HUMAN (1-530): 2.38e-157: 460: 100.00
+	Hs
		517813 NFH_HUMAN (59-453): 6.56e-12: 71.3: 19.25		ESR2_HUMAN (1-530): 2.38e-157: 460: 100.00
+	Hs
		1264774 TITIN_HUMAN (8-622): 2.9e-11: 69.6: 12.44		ESR2_HUMAN (1-530): 2.38e-157: 460: 100.00
+	Hs
		1154059 NIPBL_HUMAN (62-535): 1.22e-09: 63.9: 13.77		ESR2_HUMAN (1-530): 2.38e-157: 460: 100.00
+	Mm
		521439 TOP2A_MOUSE (6-368): 7.3e-51: 194: 16.17		NR4A1_MOUSE (7-501): 1.18e-103: 325: 25.35
+	Hs
		370263 MINT_HUMAN (28-674): 3.38e-12: 72.4: 11.90		ESR1_HUMAN (9-529): 3.58e-138: 413: 44.56
+	Hs
		508823 TOP2A_HUMAN (6-372): 1.49e-41: 165: 14.44		NR4A1_HUMAN (7-501): 3.18e-101: 318: 25.30
+	Hs
		370105 TITIN_HUMAN (8-622): 2.9e-11: 69.6: 12.44		ESR1_HUMAN (9-529): 3.58e-138: 413: 44.56
+	Hs
		369815 NIPBL_HUMAN (62-535): 1.22e-09: 63.9: 13.77		ESR1_HUMAN (9-529): 3.58e-138: 413: 44.56
+	Hs
		782640 MINT_HUMAN (28-674): 3.38e-12: 72.4: 11.90		HNF4A_HUMAN (94-502): 1.21e-107: 331: 23.30
+	Hs
		377624 MINT_HUMAN (28-674): 3.38e-12: 72.4: 11.90		GCR_HUMAN (3-495): 1.12e-103: 330: 22.64
+	Hs
		377539 TITIN_HUMAN (8-622): 2.9e-11: 69.6: 12.44		GCR_HUMAN (3-495): 1.12e-103: 330: 22.64
+	Hs
		782571 NIPBL_HUMAN (62-535): 1.22e-09: 63.9: 13.77		HNF4A_HUMAN (94-502): 1.21e-107: 331: 23.30
+	Hs
		488014 PRAM_HUMAN (354-673): 9.68e-12: 70.4: 9.54		RARA_HUMAN (52-505): 3.54e-105: 324: 23.74
+	Hs
		377401 NIPBL_HUMAN (62-535): 1.22e-09: 63.9: 13.77		GCR_HUMAN (3-495): 1.12e-103: 330: 22.64
+	Hs
		487348 TOP2B_HUMAN (6-463): 1.53e-66: 241: 14.13		ANDR_HUMAN (149-407): 8.1e-38: 150: 32.59
+	Hs
		487522 NIPBL_HUMAN (62-535): 1.22e-09: 63.9: 13.77		ANDR_HUMAN (149-407): 8.1e-38: 150: 32.59