HitPredict

Interactor 1: NUMA1 (Q14980)
Nuclear mitotic apparatus protein 1 (Nuclear matrix protein-22) (NMP-22) (Nuclear mitotic apparatus protein) (NuMA protein) (SP-H antigen)
Gene: NUMA1

Interactor 2: CCD57 (Q2TAC2)
Coiled-coil domain-containing protein 57
Gene: CCDC57

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.66	0.60	0.631

Property	Details
Experiments	25416956, 23718855
Identification Methods	two hybrid, affinity chromatography technology, two hybrid prey pooling approach, two hybrid array, validated two hybrid
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005813 - centrosome GO:0005876 - spindle microtubule
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 2115 Hs			1 915
+	Hs
		148830 NUMA1_HUMAN (1-2115): 1.36e-162: 555: 100.00		CTRO_HUMAN (11-592): 3.61e-19: 95.8: 13.83
+	Hs
		724994 CP250_HUMAN (1-1659): 6.01e-59: 228: 13.08		MYH9_HUMAN (441-910): 7.24e-15: 81.7: 11.34
+	Hs
		148460 MYH9_HUMAN (1033-1891): 1.22e-33: 145: 10.62		CTRO_HUMAN (11-592): 3.61e-19: 95.8: 13.83
+	Hs
		724687 MYH9_HUMAN (1033-1891): 1.22e-33: 145: 10.62		MYH10_HUMAN (1-514): 8.43e-19: 94.4: 12.69
+	Hs
		148461 MYH10_HUMAN (1281-2075): 5.26e-33: 142: 12.34		CTRO_HUMAN (11-592): 3.61e-19: 95.8: 13.83
+	Hs
		725095 MYH10_HUMAN (1281-2075): 5.26e-33: 142: 12.34		MYH10_HUMAN (1-514): 8.43e-19: 94.4: 12.69
+	Hs
		148841 PLEC_HUMAN (45-1230): 3.46e-32: 140: 13.37		CTRO_HUMAN (11-592): 3.61e-19: 95.8: 13.83
+	Hs
		522585 MYH7_HUMAN (947-2023): 1.11e-36: 155: 11.21		MYH7_HUMAN (441-899): 6.17e-14: 78.6: 9.03
+	Hs
		724686 MYH9_HUMAN (1033-1891): 1.22e-33: 145: 10.62		MYH9_HUMAN (441-910): 7.24e-15: 81.7: 11.34
+	Hs
		522657 MYH7_HUMAN (947-2023): 1.11e-36: 155: 11.21		MYH4_HUMAN (504-909): 4.67e-11: 69.4: 10.98
+	Hs
		502933 MYH4_HUMAN (1-831): 9.18e-34: 145: 12.50		MYH3_HUMAN (390-913): 2.46e-13: 76.7: 11.15
+	Hs
		528435 MYH8_HUMAN (1122-2115): 6.23e-35: 149: 10.31		MYH4_HUMAN (504-909): 4.67e-11: 69.4: 10.98
+	Hs
		725097 MYH10_HUMAN (1281-2075): 5.26e-33: 142: 12.34		MYH11_HUMAN (476-915): 5.52e-13: 75.5: 9.01
+	Hs
		528432 MYH8_HUMAN (1122-2115): 6.23e-35: 149: 10.31		MYH13_HUMAN (504-915): 2.5e-09: 63.6: 10.14
+	Rn
		361106 MYH6_RAT (1-883): 3.56e-32: 140: 12.82		MYH6_RAT (1-436): 1.51e-11: 70.9: 10.48
+	Hs
		724943 MYH9_HUMAN (1033-1891): 1.22e-33: 145: 10.62		MY18A_HUMAN (115-543): 3.73e-09: 62.9: 17.00