HitPredict

Interactor 1: NR1I3 (Q14994)
Nuclear receptor subfamily 1 group I member 3 (Constitutive activator of retinoid response) (Constitutive active response) (Constitutive androstane receptor) (CAR) (Orphan nuclear receptor MB67)
Gene: NR1I3

Interactor 2: MED4 (Q9NPJ6)
Mediator of RNA polymerase II transcription subunit 4 (Activator-recruited cofactor 36 kDa component) (ARC36) (Mediator complex subunit 4) (TRAP/SMCC/PC2 subunit p36 subunit) (Vitamin D3 receptor-interacting protein complex 36 kDa component) (DRIP36)
Gene: MED4

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.74	0.60	0.667

Property	Details
Experiments	26186194, 28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm
Homologous interactions	6

Homologous interactions

Color coding for hit scores

	1 352 Hs			1 270
+	Hs
		509988 VDR_HUMAN (8-351): 4.64e-105: 316: 33.74		MED4_HUMAN (1-258): 3.31e-135: 384: 100.00
+	Hs
		782668 HNF4A_HUMAN (2-351): 3.85e-101: 308: 24.43		MED4_HUMAN (1-258): 3.31e-135: 384: 100.00
+	Mm
		1142716 ERR2_MOUSE (7-351): 8.22e-91: 280: 23.63		MED4_MOUSE (1-258): 6.74e-143: 403: 94.57
+	Hs
		370501 ESR1_HUMAN (2-351): 1.82e-94: 294: 21.66		MED4_HUMAN (1-258): 3.31e-135: 384: 100.00
+	Hs
		488026 RARA_HUMAN (9-351): 2.99e-95: 292: 28.12		MED4_HUMAN (1-258): 3.31e-135: 384: 100.00
+	Hs
		1269697 ESR2_HUMAN (2-352): 4.23e-88: 276: 21.76		MED4_HUMAN (1-258): 3.31e-135: 384: 100.00