HitPredict

Interactor 1: NR1I3 (Q14994)
Nuclear receptor subfamily 1 group I member 3 (Constitutive activator of retinoid response) (Constitutive active response) (Constitutive androstane receptor) (CAR) (Orphan nuclear receptor MB67)
Gene: NR1I3

Interactor 2: MED23 (Q9ULK4)
Mediator of RNA polymerase II transcription subunit 23 (Activator-recruited cofactor 130 kDa component) (ARC130) (Cofactor required for Sp1 transcriptional activation subunit 3) (CRSP complex subunit 3) (Mediator complex subunit 23) (Protein sur-2 homolog) (hSur-2) (Transcriptional coactivator CRSP130) (Vitamin D3 receptor-interacting protein complex 130 kDa component) (DRIP130)
Gene: MED23

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.74	0.60	0.667

Property	Details
Experiments	26186194, 28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm
Homologous interactions	5

Homologous interactions

Color coding for hit scores

	1 352 Hs			1 1368
+	Hs
		509994 VDR_HUMAN (8-351): 4.64e-105: 316: 33.74		MED23_HUMAN (1-1368): 0: 2164: 100.00
+	Hs
		782691 HNF4A_HUMAN (2-351): 3.85e-101: 308: 24.43		MED23_HUMAN (1-1368): 0: 2164: 100.00
+	Hs
		370690 ESR1_HUMAN (2-351): 1.82e-94: 294: 21.66		MED23_HUMAN (1-1368): 0: 2164: 100.00
+	Hs
		1269910 ESR2_HUMAN (2-352): 4.23e-88: 276: 21.76		MED23_HUMAN (1-1368): 0: 2164: 100.00
+	Mm
		1142670 ERR2_MOUSE (7-351): 8.22e-91: 280: 23.63		MED23_MOUSE (1-1368): 0: 2083: 96.27