HitPredict

Interactor 1: SHPRH (Q149N8)
E3 ubiquitin-protein ligase SHPRH (EC 2.3.2.27) (EC 3.6.4.-) (RING-type E3 ubiquitin transferase SHPRH) (SNF2, histone-linker, PHD and RING finger domain-containing helicase)
Gene: SHPRH

Interactor 2: SIN3A (Q96ST3)
Paired amphipathic helix protein Sin3a (Histone deacetylase complex subunit Sin3a) (Transcriptional corepressor Sin3a)
Gene: SIN3A

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	24981860
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003677 - DNA binding GO:0005654 - nucleoplasm
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 1683 Hs			1 1273
+	Hs
		229469 SMCA5_HUMAN (1267-1682): 2.48e-107: 370: 15.44		SIN3A_HUMAN (1-1273): 0: 1545: 100.00
+	Hs
		1018652 CHD3_HUMAN (1279-1682): 6.88e-103: 368: 17.87		SIN3A_HUMAN (1-1273): 0: 1545: 100.00
+	Hs
		847060 SMCA4_HUMAN (1246-1682): 3.38e-96: 346: 13.91		SIN3A_HUMAN (1-1273): 0: 1545: 100.00
+	Hs
		1059812 CHD4_HUMAN (1275-1682): 1.8e-95: 345: 17.70		SIN3A_HUMAN (1-1273): 0: 1545: 100.00
+	Hs
		846854 SMCA2_HUMAN (1161-1676): 4.99e-95: 342: 13.08		SIN3A_HUMAN (1-1273): 0: 1545: 100.00
+	Hs
		658721 SMCA1_HUMAN (1315-1682): 8.95e-71: 261: 16.12		SIN3A_HUMAN (1-1273): 0: 1545: 100.00
+	Hs
		257784 SHPRH_HUMAN (1-1683): 0: 1247: 100.00		SIN3B_HUMAN (20-331): 1.12e-13: 78.4: 16.15
+	Ce
		60807 LE418_CAEEL (1276-1682): 1.32e-98: 354: 16.75		SIN3_CAEEL (60-1079): 0: 716: 19.90
+	Ce
		60817 SWSN4_CAEEL (887-1676): 1.48e-76: 283: 12.87		SIN3_CAEEL (60-1079): 0: 716: 19.90
+	Ce
		60864 P91494_CAEEL (1492-1675): 7.69e-49: 192: 26.32		SIN3_CAEEL (60-1079): 0: 716: 19.90
+	Sp
		194433 FFT3_SCHPO (1516-1663): 1.54e-12: 74.7: 32.90		PST1_SCHPO (21-1219): 0: 796: 25.91
+	Sp
		194186 FFT3_SCHPO (1516-1663): 1.54e-12: 74.7: 32.90		PST3_SCHPO (5-1216): 0: 762: 22.04
+	Hs
		257809 CHD5_HUMAN (1253-1682): 1.55e-104: 373: 17.96		SIN3B_HUMAN (20-331): 1.12e-13: 78.4: 16.15
+	Hs
		257774 CHD3_HUMAN (1279-1682): 6.88e-103: 368: 17.87		SIN3B_HUMAN (20-331): 1.12e-13: 78.4: 16.15
+	Hs
		257757 SMCA4_HUMAN (1246-1682): 3.38e-96: 346: 13.91		SIN3B_HUMAN (20-331): 1.12e-13: 78.4: 16.15
+	Hs
		257756 SMCA2_HUMAN (1161-1676): 4.99e-95: 342: 13.08		SIN3B_HUMAN (20-331): 1.12e-13: 78.4: 16.15
+	Hs
		257742 SMCA1_HUMAN (1315-1682): 8.95e-71: 261: 16.12		SIN3B_HUMAN (20-331): 1.12e-13: 78.4: 16.15
+	Sc
		609055 BTAF1_YEAST (1499-1675): 1.74e-12: 75.1: 30.98		SIN3_YEAST (20-499): 1.06e-32: 140: 14.02