HitPredict

Interactor 1: PSMD6 (Q15008)
26S proteasome non-ATPase regulatory subunit 6 (26S proteasome regulatory subunit RPN7) (26S proteasome regulatory subunit S10) (Breast cancer-associated protein SGA-113M) (Phosphonoformate immuno-associated protein 4) (Proteasome regulatory particle subunit p44S10) (p42A)
Gene: PSMD6

Interactor 2: UBQL1 (Q9UMX0)
Ubiquilin-1 (Protein linking IAP with cytoskeleton 1) (PLIC-1) (hPLIC-1)
Gene: UBQLN1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.66	1.00	0.815

Property	Details
Experiments	25416956, 27114451
Identification Methods	two hybrid, affinity chromatography technology, two hybrid prey pooling approach, two hybrid array, validated two hybrid
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	RPN7~ubiquitin
Common GO terms	GO:0000502 - proteasome complex GO:0005654 - nucleoplasm GO:0005829 - cytosol
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 389 Hs			1 589
+	Hs
		1062891 PSMD6_HUMAN (1-389): 5.58e-137: 397: 100.00		UBQL2_HUMAN (1-589): 9.51e-145: 433: 71.29
+	Hs
		1062884 PSMD6_HUMAN (1-389): 5.58e-137: 397: 100.00		UBQL4_HUMAN (28-589): 1.35e-135: 409: 57.64
+	Dm
		1358537 PSMD6_DROME (1-389): 2.36e-125: 368: 70.18		Q9VWD9_DROME (30-582): 3.32e-135: 407: 47.39
+	Hs
		121871 PSD11_HUMAN (3-387): 8.54e-77: 245: 11.03		UBQL1_HUMAN (1-589): 1.23e-174: 509: 100.00
+	Hs
		121867 PSD11_HUMAN (3-387): 8.54e-77: 245: 11.03		UBQL2_HUMAN (1-589): 9.51e-145: 433: 71.29
+	Hs
		888457 EIF3E_HUMAN (26-387): 7.71e-74: 238: 14.04		UBQL2_HUMAN (1-589): 9.51e-145: 433: 71.29
+	Hs
		121863 PSD11_HUMAN (3-387): 8.54e-77: 245: 11.03		UBQL4_HUMAN (28-589): 1.35e-135: 409: 57.64
+	Dm
		1180727 PSD11_DROME (7-387): 4.3e-77: 246: 13.32		Q9VWD9_DROME (30-582): 3.32e-135: 407: 47.39
+	Hs
		1062848 PSMD6_HUMAN (1-389): 5.58e-137: 397: 100.00		DDI1_HUMAN (47-318): 6.39e-53: 187: 15.60
+	Hs
		1062825 PSMD6_HUMAN (1-389): 5.58e-137: 397: 100.00		DDI2_HUMAN (47-318): 2.03e-49: 178: 13.52
+	Dm
		1358524 PSMD6_DROME (1-389): 2.36e-125: 368: 70.18		Q9V3W9_DROME (37-394): 1.42e-40: 154: 13.95
+	Hs
		923997 PSMD6_HUMAN (1-389): 5.58e-137: 397: 100.00		RS27A_HUMAN (37-123): 1.1e-12: 68: 30.68
+	Hs
		121821 PSD11_HUMAN (3-387): 8.54e-77: 245: 11.03		DDI1_HUMAN (47-318): 6.39e-53: 187: 15.60
+	Hs
		121791 PSD11_HUMAN (3-387): 8.54e-77: 245: 11.03		DDI2_HUMAN (47-318): 2.03e-49: 178: 13.52
+	Sc
		697117 RPN7_YEAST (11-389): 3.41e-86: 269: 35.47		RAD23_YEAST (45-419): 1.17e-31: 128: 17.73
+	Hs
		121731 PSD11_HUMAN (3-387): 8.54e-77: 245: 11.03		RL40_HUMAN (37-126): 1.88e-34: 128: 30.77
+	Sc
		697128 RPN6_YEAST (30-389): 1.53e-56: 192: 12.57		RAD23_YEAST (45-419): 1.17e-31: 128: 17.73
+	Hs
		121730 PSD11_HUMAN (3-387): 8.54e-77: 245: 11.03		RS27A_HUMAN (37-123): 1.1e-12: 68: 30.68