Interactor 1: HERP1 (Q15011)
Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 1 protein (Methyl methanesulfonate (MMF)-inducible fragment protein 1)
Gene: HERPUD1

Interactor 2: AMFR (Q9UKV5)
E3 ubiquitin-protein ligase AMFR (EC 2.3.2.36) (Autocrine motility factor receptor) (AMF receptor) (RING finger protein 45) (gp78)
Gene: AMFR

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.93 1.00 0.968

The method score is based on:

Property Details
Experiments 25409783, 19223579, 24366945, 26424800, 17310145, 21965653, 24496447, 21636303
Identification Methods enzymatic study, pull down, affinity chromatography technology
Interaction Type direct interaction, physical association

The annotation score is based on:

Property Details
Interacting Pfam domains CUE~ubiquitin, ubiquitin~zf-RING_2
Common GO terms GO:0005783 - endoplasmic reticulum
GO:0005789 - endoplasmic reticulum membrane
GO:0006511 - ubiquitin-dependent protein catabolic process
GO:0016020 - membrane
GO:0030968 - endoplasmic reticulum unfolded protein response
and 1 others

more...

Homologous interactions 2

Homologous interactions

Color coding for hit scores

1 391
Hs

1 643
+ Hs
+ Hs

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024