HitPredict

Interactor 1: TNIP1 (Q15025)
TNFAIP3-interacting protein 1 (A20-binding inhibitor of NF-kappa-B activation 1) (ABIN-1) (HIV-1 Nef-interacting protein) (Nef-associated factor 1) (Naf1) (Nip40-1) (Virion-associated nuclear shuttling protein) (VAN) (hVAN)
Gene: TNIP1

Interactor 2: SHC3 (Q92529)
SHC-transforming protein 3 (Neuronal Shc) (N-Shc) (Protein Rai) (SHC-transforming protein C) (Src homology 2 domain-containing-transforming protein C3) (SH2 domain protein C3)
Gene: SHC3

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	36574265
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 636 Hs			1 594
+	Hs
		1063883 TNIP1_HUMAN (1-636): 6.24e-78: 262: 100.00		SHC4_HUMAN (1-593): 1.37e-158: 469: 43.61
+	Hs
		666020 MYH11_HUMAN (154-571): 3.35e-18: 91.5: 11.11		SHC1_HUMAN (3-593): 5.76e-176: 512: 46.65
+	Hs
		666019 MYH10_HUMAN (210-571): 5.78e-13: 74.6: 10.48		SHC1_HUMAN (3-593): 5.76e-176: 512: 46.65
+	Hs
		666018 MYH9_HUMAN (267-566): 1.17e-09: 63.8: 13.33		SHC1_HUMAN (3-593): 5.76e-176: 512: 46.65
+	Hs
		275571 TNIP1_HUMAN (1-636): 6.24e-78: 262: 100.00		BCAR3_HUMAN (342-592): 6.06e-51: 190: 21.13
+	Hs
		412197 TNIP1_HUMAN (1-636): 6.24e-78: 262: 100.00		FYN_HUMAN (438-585): 3.12e-44: 167: 20.76
+	Mm
		1206702 ITSN1_MOUSE (27-390): 6.77e-14: 77.7: 12.43		ANS1B_MOUSE (11-331): 1.47e-68: 243: 17.68
+	Hs
		523231 MYH4_HUMAN (2-476): 3.89e-17: 88: 8.73		SRC_HUMAN (361-594): 3.73e-49: 181: 18.18
+	Hs
		433818 MRCKA_HUMAN (38-480): 1.13e-18: 92.8: 12.23		LYN_HUMAN (404-594): 8.1e-44: 165: 20.69
+	Hs
		111443 MYH9_HUMAN (267-566): 1.17e-09: 63.8: 13.33		J3QRU1_HUMAN (355-594): 1.49e-48: 179: 17.31
+	Hs
		433272 MYH9_HUMAN (267-566): 1.17e-09: 63.8: 13.33		YES_HUMAN (355-594): 1.37e-48: 179: 17.31
+	Hs
		433781 ITSN1_HUMAN (92-469): 5.76e-14: 77.7: 11.00		LYN_HUMAN (404-594): 8.1e-44: 165: 20.69
+	Hs
		434101 MRCKB_HUMAN (20-413): 8.06e-13: 73.9: 11.39		LYN_HUMAN (404-594): 8.1e-44: 165: 20.69
+	Hs
		412058 MYH9_HUMAN (267-566): 1.17e-09: 63.8: 13.33		FYN_HUMAN (438-585): 3.12e-44: 167: 20.76
+	Hs
		433620 MYH9_HUMAN (267-566): 1.17e-09: 63.8: 13.33		LYN_HUMAN (404-594): 8.1e-44: 165: 20.69
+	Hs
		434048 DAPLE_HUMAN (47-529): 4.09e-09: 61.9: 12.81		LYN_HUMAN (404-594): 8.1e-44: 165: 20.69
+	Hs
		433795 GRDN_HUMAN (154-540): 6.14e-09: 61.6: 9.92		LYN_HUMAN (404-594): 8.1e-44: 165: 20.69
+	Hs
		728465 MYH11_HUMAN (154-571): 3.35e-18: 91.5: 11.11		GRB2_HUMAN (445-594): 1.28e-34: 132: 22.08
+	Hs
		725134 MYH10_HUMAN (210-571): 5.78e-13: 74.6: 10.48		GRB2_HUMAN (445-594): 1.28e-34: 132: 22.08
+	Hs
		724756 MYH9_HUMAN (267-566): 1.17e-09: 63.8: 13.33		GRB2_HUMAN (445-594): 1.28e-34: 132: 22.08