HitPredict

Interactor 1: G5EDY3 (G5EDY3)
Skp1-related protein
Gene: skr-7

Interactor 2: CUL1 (Q17389)
Cullin-1 (CUL-1) (Abnormal cell lineage protein 19)
Gene: cul-1

Species: Caenorhabditis elegans

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.63	1.00	0.800

Property	Details
Experiments	11864567, 11864566
Identification Methods	two hybrid, affinity chromatography technology
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	Cullin~Skp1_POZ
Common GO terms	GO:0005737 - cytoplasm GO:0016567 - protein ubiquitination GO:0031146 - SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 194 Ce			1 780
+	Mm
		1376703 SKP1_MOUSE (21-180): 1.27e-81: 240: 39.51		CUL1_MOUSE (2-780): 0: 822: 45.71
+	Hs
		928899 SKP1_HUMAN (21-180): 2.58e-81: 240: 39.51		CUL1_HUMAN (2-780): 0: 822: 45.71
+	Ce
		105467 SKR1_CAEEL (11-179): 8.93e-80: 236: 35.84		CUL1_CAEEL (1-780): 0: 823: 100.00
+	Ce
		105999 G5EDD8_CAEEL (11-179): 1.71e-69: 210: 38.01		CUL1_CAEEL (1-780): 0: 823: 100.00
+	Ce
		108000 G5EG39_CAEEL (1-194): 8.23e-68: 207: 85.57		CUL1_CAEEL (1-780): 0: 823: 100.00
+	Hs
		928902 SKP1_HUMAN (21-180): 2.58e-81: 240: 39.51		CUL4A_HUMAN (3-780): 0: 770: 26.50
+	Hs
		928903 SKP1_HUMAN (21-180): 2.58e-81: 240: 39.51		CUL4B_HUMAN (3-780): 0: 755: 25.99
+	Hs
		928901 SKP1_HUMAN (21-180): 2.58e-81: 240: 39.51		CUL3_HUMAN (7-780): 0: 752: 25.77
+	Dm
		284976 O77430_DROME (21-180): 1.76e-75: 225: 34.57		CUL1_DROME (3-780): 0: 746: 41.92
+	Dm
		1097192 Q7KJ69_DROME (21-180): 1.68e-70: 212: 33.33		CUL1_DROME (3-780): 0: 746: 41.92
+	Dm
		284981 O77430_DROME (21-180): 1.76e-75: 225: 34.57		Q5BI50_DROME (3-780): 0: 727: 26.85
+	Hs
		928900 SKP1_HUMAN (21-180): 2.58e-81: 240: 39.51		CUL2_HUMAN (9-780): 0: 708: 30.84
+	At
		1277333 ASK4_ARATH (19-179): 9.55e-74: 221: 33.94		CUL1_ARATH (8-780): 0: 713: 26.86
+	At
		1277346 ASK3_ARATH (19-179): 2.16e-72: 217: 32.73		CUL1_ARATH (8-780): 0: 713: 26.86
+	At
		221655 ASK11_ARATH (19-179): 1.37e-71: 215: 31.06		CUL1_ARATH (8-780): 0: 713: 26.86
+	At
		1277329 SKP1B_ARATH (17-179): 2.63e-70: 212: 30.11		CUL1_ARATH (8-780): 0: 713: 26.86
+	At
		1107618 SKP1A_ARATH (19-179): 4.55e-70: 211: 29.27		CUL1_ARATH (8-780): 0: 713: 26.86
+	At
		1277337 ASK10_ARATH (19-179): 7.4e-69: 208: 28.57		CUL1_ARATH (8-780): 0: 713: 26.86
+	Sp
		142922 SKP1_SCHPO (21-180): 1.62e-71: 215: 34.76		CUL1_SCHPO (8-780): 0: 706: 32.53
+	Hs
		929020 SKP1_HUMAN (21-180): 2.58e-81: 240: 39.51		CUL5_HUMAN (2-780): 0: 614: 25.03