HitPredict

Interactor 1: SYK (Q15046)
Lysine--tRNA ligase (EC 2.7.7.-) (EC 6.1.1.6) (Lysyl-tRNA synthetase) (LysRS)
Gene: KARS1

Interactor 2: SYLC (Q9P2J5)
Leucine--tRNA ligase, cytoplasmic (EC 6.1.1.4) (Leucyl-tRNA synthetase) (LeuRS) (cLRS)
Gene: LARS1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.65	0.60	0.628

Property	Details
Experiments	28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005524 - ATP binding GO:0005829 - cytosol GO:0017101 - aminoacyl-tRNA synthetase multienzyme complex
Homologous interactions	12

Homologous interactions

Color coding for hit scores

	1 597 Hs			1 1176
+	Hs
		541427 SYDC_HUMAN (116-572): 6.4e-133: 399: 19.63		SYLC_HUMAN (1-1176): 0: 1211: 100.00
+	Hs
		783040 SYK_HUMAN (1-597): 0: 765: 100.00		SYIC_HUMAN (5-1136): 0: 692: 15.44
+	Sc
		546147 SYKC_YEAST (2-586): 0: 603: 55.31		SYLC_YEAST (5-1063): 0: 795: 44.18
+	Sc
		430745 SYKC_YEAST (2-586): 0: 603: 55.31		SYV_YEAST (9-998): 0: 638: 14.78
+	Sc
		389056 SYDC_YEAST (3-572): 1.36e-140: 421: 20.30		SYLC_YEAST (5-1063): 0: 795: 44.18
+	Sc
		643666 SYNC_YEAST (12-572): 4.15e-139: 417: 18.78		SYLC_YEAST (5-1063): 0: 795: 44.18
+	Ec
		343736 SYK2_ECOLI (60-577): 0: 552: 42.58		SYI_ECOLI (5-983): 0: 603: 13.97
+	Hs
		541324 SYDC_HUMAN (116-572): 6.4e-133: 399: 19.63		SYIC_HUMAN (5-1136): 0: 692: 15.44
+	Sc
		389036 SYDC_YEAST (3-572): 1.36e-140: 421: 20.30		SYV_YEAST (9-998): 0: 638: 14.78
+	Sc
		430774 SYNC_YEAST (12-572): 4.15e-139: 417: 18.78		SYV_YEAST (9-998): 0: 638: 14.78
+	Sc
		450305 SYNC_YEAST (12-572): 4.15e-139: 417: 18.78		SYIC_YEAST (11-1151): 0: 624: 13.58
+	Dm
		1178626 Q7K0E6_DROME (126-572): 5.01e-129: 390: 20.00		Q8MSW0_DROME (7-1129): 0: 646: 15.02