HitPredict

Interactor 1: SETB1 (Q15047)
Histone-lysine N-methyltransferase SETDB1 (EC 2.1.1.366) (ERG-associated protein with SET domain) (ESET) (Histone H3-K9 methyltransferase 4) (H3-K9-HMTase 4) (Lysine N-methyltransferase 1E) (SET domain bifurcated 1)
Gene: SETDB1

Interactor 2: H32 (Q71DI3)
Histone H3.2 (H3-clustered histone 13) (H3-clustered histone 14) (H3-clustered histone 15) (Histone H3/m) (Histone H3/o)
Gene: H3C15

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.647

Property	Details
Experiments	11959841
Identification Methods	pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	Histone~SET
Common GO terms	GO:0003677 - DNA binding GO:0005634 - nucleus GO:0005654 - nucleoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1291 Hs			1 136
+	Hs
		934780 SETB1_HUMAN (1-1291): 0: 1373: 100.00		H31_HUMAN (1-136): 1.98e-62: 189: 99.27
+	Hs
		935251 EHMT1_HUMAN (995-1287): 5.59e-70: 259: 21.27		H31_HUMAN (1-136): 1.98e-62: 189: 99.27
+	Hs
		1086320 EHMT1_HUMAN (995-1287): 5.59e-70: 259: 21.27		H31T_HUMAN (1-136): 8.3e-62: 187: 96.32
+	Hs
		952633 EHMT1_HUMAN (995-1287): 5.59e-70: 259: 21.27		H33_HUMAN (1-136): 1.59e-61: 186: 97.06
+	Hs
		203659 SUV91_HUMAN (658-972): 1.59e-70: 244: 22.56		H31_HUMAN (1-136): 1.98e-62: 189: 99.27
+	Hs
		203664 SUV91_HUMAN (658-972): 1.59e-70: 244: 22.56		H33_HUMAN (1-136): 1.59e-61: 186: 97.06
+	Hs
		203722 SUV91_HUMAN (658-972): 1.59e-70: 244: 22.56		H32_HUMAN (1-136): 3.73e-61: 186: 100.00
+	Hs
		935126 EHMT2_HUMAN (999-1287): 2.75e-64: 241: 19.11		H31_HUMAN (1-136): 1.98e-62: 189: 99.27
+	Mm
		952777 EHMT2_MOUSE (999-1287): 7.04e-65: 243: 19.11		H33_MOUSE (1-136): 1.59e-61: 186: 97.06
+	Hs
		1086279 EHMT2_HUMAN (999-1287): 2.75e-64: 241: 19.11		H31T_HUMAN (1-136): 8.3e-62: 187: 96.32
+	Hs
		1174632 EHMT2_HUMAN (999-1287): 2.75e-64: 241: 19.11		H32_HUMAN (1-136): 3.73e-61: 186: 100.00
+	Hs
		952553 EHMT2_HUMAN (999-1287): 2.75e-64: 241: 19.11		H33_HUMAN (1-136): 1.59e-61: 186: 97.06
+	Hs
		203706 SUV91_HUMAN (658-972): 1.59e-70: 244: 22.56		H37_HUMAN (1-136): 3.26e-59: 181: 97.06
+	Hs
		935237 SUV92_HUMAN (973-1290): 2.24e-67: 235: 20.98		H31_HUMAN (1-136): 1.98e-62: 189: 99.27
+	Hs
		203711 SUV91_HUMAN (658-972): 1.59e-70: 244: 22.56		H3C_HUMAN (1-136): 8.83e-59: 179: 94.12
+	Hs
		952627 SUV92_HUMAN (973-1290): 2.24e-67: 235: 20.98		H33_HUMAN (1-136): 1.59e-61: 186: 97.06
+	At
		886462 SUVH4_ARATH (974-1291): 3.06e-63: 229: 18.21		H33_ARATH (1-136): 4.35e-62: 188: 96.32
+	Hs
		828381 EHMT1_HUMAN (995-1287): 5.59e-70: 259: 21.27		CENPA_HUMAN (9-133): 2.85e-44: 143: 50.00
+	Hs
		935204 SETD2_HUMAN (911-1290): 1.29e-53: 209: 16.00		H31_HUMAN (1-136): 1.98e-62: 189: 99.27
+	Hs
		1086306 SETD2_HUMAN (911-1290): 1.29e-53: 209: 16.00		H31T_HUMAN (1-136): 8.3e-62: 187: 96.32