HitPredict

Interactor 1: SETB1 (Q15047)
Histone-lysine N-methyltransferase SETDB1 (EC 2.1.1.366) (ERG-associated protein with SET domain) (ESET) (Histone H3-K9 methyltransferase 4) (H3-K9-HMTase 4) (Lysine N-methyltransferase 1E) (SET domain bifurcated 1)
Gene: SETDB1

Interactor 2: DNM3B (Q9UBC3)
DNA (cytosine-5)-methyltransferase 3B (Dnmt3b) (EC 2.1.1.37) (DNA methyltransferase HsaIIIB) (DNA MTase HsaIIIB) (M.HsaIIIB)
Gene: DNMT3B

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.44	0.60	0.515

Property	Details
Experiments	16682412
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003677 - DNA binding GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0032259 - methylation
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 1291 Hs			1 853
+	Hs
		1065769 SETB1_HUMAN (1-1291): 0: 1373: 100.00		DNM3A_HUMAN (30-852): 0: 1126: 49.82
+	Mm
		291723 SETB1_MOUSE (1-1291): 0: 1335: 90.61		DNM3A_MOUSE (30-852): 0: 1148: 50.36
+	Hs
		203801 SUV91_HUMAN (658-972): 1.59e-70: 244: 22.56		DNM3B_HUMAN (1-853): 0: 1352: 100.00
+	Hs
		1296428 EHMT2_HUMAN (999-1287): 2.75e-64: 241: 19.11		DNM3B_HUMAN (1-853): 0: 1352: 100.00
+	Hs
		1080430 EZH2_HUMAN (1026-1272): 1.18e-48: 188: 13.13		DNM3B_HUMAN (1-853): 0: 1352: 100.00
+	Mm
		291753 EHMT2_MOUSE (999-1287): 7.04e-65: 243: 19.11		DNM3B_MOUSE (1-853): 0: 1226: 81.38
+	Mm
		291747 EZH2_MOUSE (1026-1272): 1.15e-48: 188: 13.13		DNM3B_MOUSE (1-853): 0: 1226: 81.38
+	Mm
		291729 EHMT1_MOUSE (995-1287): 2.13e-66: 248: 21.84		DNM3A_MOUSE (30-852): 0: 1148: 50.36
+	Mm
		291740 EHMT2_MOUSE (999-1287): 7.04e-65: 243: 19.11		DNM3A_MOUSE (30-852): 0: 1148: 50.36
+	Hs
		1334149 EHMT1_HUMAN (995-1287): 5.59e-70: 259: 21.27		DNM3A_HUMAN (30-852): 0: 1126: 49.82
+	Hs
		203822 SUV91_HUMAN (658-972): 1.59e-70: 244: 22.56		DNM3A_HUMAN (30-852): 0: 1126: 49.82
+	Hs
		1296452 EHMT2_HUMAN (999-1287): 2.75e-64: 241: 19.11		DNM3A_HUMAN (30-852): 0: 1126: 49.82
+	Mm
		291731 EZH2_MOUSE (1026-1272): 1.15e-48: 188: 13.13		DNM3A_MOUSE (30-852): 0: 1148: 50.36
+	Hs
		1080532 EZH2_HUMAN (1026-1272): 1.18e-48: 188: 13.13		DNM3A_HUMAN (30-852): 0: 1126: 49.82
+	Mm
		1321845 EHMT2_MOUSE (999-1287): 7.04e-65: 243: 19.11		DNM3L_MOUSE (417-757): 8.49e-157: 466: 36.34
+	Mm
		1142293 EZH2_MOUSE (1026-1272): 1.15e-48: 188: 13.13		DNM3L_MOUSE (417-757): 8.49e-157: 466: 36.34
+	Hs
		1271098 EZH1_HUMAN (1026-1272): 2.97e-55: 208: 14.29		PWP2A_HUMAN (45-310): 1.4e-63: 230: 19.50
+	Hs
		1080249 EZH2_HUMAN (1026-1272): 1.18e-48: 188: 13.13		PWP2A_HUMAN (45-310): 1.4e-63: 230: 19.50