HitPredict

Interactor 1: RRS1 (Q15050)
Ribosome biogenesis regulatory protein homolog
Gene: RRS1

Interactor 2: BRX1 (Q8TDN6)
Ribosome biogenesis protein BRX1 homolog (Brix domain-containing protein 2)
Gene: BRIX1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.65	1.00	0.811

Property	Details
Experiments	28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Brix~RRS1
Common GO terms	GO:0003723 - RNA binding GO:0005730 - nucleolus
Homologous interactions	6

Homologous interactions

Color coding for hit scores

	1 365 Hs			1 353
+	Hs
		1065883 RRS1_HUMAN (1-365): 1.3e-142: 410: 100.00		RPF2_HUMAN (106-247): 1.01e-31: 122: 22.88
+	Sc
		994463 RRS1_YEAST (18-196): 3.47e-56: 184: 37.50		BRX1_YEAST (40-305): 1.92e-92: 279: 45.32
+	Sc
		755346 RRS1_YEAST (18-196): 3.47e-56: 184: 37.50		RPF1_YEAST (4-269): 5.6e-62: 201: 15.33
+	Sc
		754929 RRS1_YEAST (18-196): 3.47e-56: 184: 37.50		SSF1_YEAST (39-230): 7.36e-18: 86.4: 14.88
+	Sc
		733965 RRS1_YEAST (18-196): 3.47e-56: 184: 37.50		RPF2_YEAST (71-267): 1.62e-13: 72.5: 19.56
+	Sp
		223477 RRS1_SCHPO (23-191): 3.18e-50: 167: 39.18		RPF2_SCHPO (106-267): 5.2e-09: 58.7: 13.74