HitPredict

Interactor 1: ARHG6 (Q15052)
Rho guanine nucleotide exchange factor 6 (Alpha-Pix) (COOL-2) (PAK-interacting exchange factor alpha) (Rac/Cdc42 guanine nucleotide exchange factor 6)
Gene: ARHGEF6

Interactor 2: RHOU (Q7L0Q8)
Rho-related GTP-binding protein RhoU (CDC42-like GTPase 1) (GTP-binding protein-like 1) (Rho GTPase-like protein ARHU) (Ryu GTPase) (Wnt-1 responsive Cdc42 homolog 1) (WRCH-1)
Gene: RHOU

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	31871319
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PH~Ras, Ras~RhoGEF
Common GO terms	GO:0005085 - guanyl-nucleotide exchange factor activity GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 776 Hs			1 258
+	Hs
		1066044 ARHG6_HUMAN (1-776): 0: 621: 100.00		RHOV_HUMAN (49-258): 3.82e-87: 260: 60.66
+	Hs
		892381 ARHG6_HUMAN (1-776): 0: 621: 100.00		RAC3_HUMAN (48-223): 1.28e-83: 249: 57.96
+	Hs
		925289 ARHG6_HUMAN (1-776): 0: 621: 100.00		RAC1_HUMAN (50-234): 2.11e-79: 239: 56.76
+	Hs
		545388 ARHG6_HUMAN (1-776): 0: 621: 100.00		RAC2_HUMAN (50-233): 5.11e-77: 233: 56.52
+	Hs
		894026 ARHG6_HUMAN (1-776): 0: 621: 100.00		CDC42_HUMAN (50-236): 2.23e-74: 226: 58.82
+	Gg
		1141019 ARHG6_CHICK (1-775): 0: 589: 73.55		Q6LC82_CHICK (50-234): 2.11e-79: 239: 56.76
+	Hs
		564535 ARHG6_HUMAN (1-776): 0: 621: 100.00		RHOQ_HUMAN (50-221): 2.69e-66: 206: 56.40
+	Hs
		1066050 ARHG6_HUMAN (1-776): 0: 621: 100.00		RHOJ_HUMAN (40-238): 2.64e-63: 199: 51.26
+	Hs
		1049724 ARHG7_HUMAN (1-719): 4.57e-168: 506: 54.22		RHOV_HUMAN (49-258): 3.82e-87: 260: 60.66
+	Hs
		1049714 ARHG7_HUMAN (1-719): 4.57e-168: 506: 54.22		RHOU_HUMAN (1-258): 1.4e-83: 252: 100.00
+	Hs
		892365 ARHG7_HUMAN (1-719): 4.57e-168: 506: 54.22		RAC3_HUMAN (48-223): 1.28e-83: 249: 57.96
+	Hs
		925271 ARHG7_HUMAN (1-719): 4.57e-168: 506: 54.22		RAC1_HUMAN (50-234): 2.11e-79: 239: 56.76
+	Hs
		545368 ARHG7_HUMAN (1-719): 4.57e-168: 506: 54.22		RAC2_HUMAN (50-233): 5.11e-77: 233: 56.52
+	Hs
		893997 ARHG7_HUMAN (1-719): 4.57e-168: 506: 54.22		CDC42_HUMAN (50-236): 2.23e-74: 226: 58.82
+	Hs
		564524 ARHG7_HUMAN (1-719): 4.57e-168: 506: 54.22		RHOQ_HUMAN (50-221): 2.69e-66: 206: 56.40
+	Hs
		1049733 ARHG7_HUMAN (1-719): 4.57e-168: 506: 54.22		RHOJ_HUMAN (40-238): 2.64e-63: 199: 51.26
+	Hs
		951449 VAV3_HUMAN (1-746): 7.26e-127: 400: 16.03		RHOG_HUMAN (48-233): 5.28e-83: 248: 48.93
+	Hs
		925718 VAV3_HUMAN (1-746): 7.26e-127: 400: 16.03		RAC1_HUMAN (50-234): 2.11e-79: 239: 56.76
+	Hs
		901037 VAV3_HUMAN (1-746): 7.26e-127: 400: 16.03		RHOA_HUMAN (51-232): 1.24e-77: 234: 46.15
+	Hs
		548671 VAV_HUMAN (1-746): 1.59e-120: 384: 16.20		CDC42_HUMAN (50-236): 2.23e-74: 226: 58.82