HitPredict

Interactor 1: BRD3 (Q15059)
Bromodomain-containing protein 3 (RING3-like protein)
Gene: BRD3

Interactor 2: TAF3 (Q5VWG9)
Transcription initiation factor TFIID subunit 3 (140 kDa TATA box-binding protein-associated factor) (TBP-associated factor 3) (Transcription initiation factor TFIID 140 kDa subunit) (TAF(II)140) (TAF140) (TAFII-140) (TAFII140)
Gene: TAF3

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.56	1.00	0.754

Property	Details
Experiments	31753913, 30554943
Identification Methods	affinity chromatography technology, proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Bromodomain~PHD
Common GO terms	GO:0005634 - nucleus GO:0045944 - positive regulation of transcription by RNA polymerase II
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 726 Hs			1 929
+	Hs
		631460 BRD2_HUMAN (5-700): 1.46e-129: 405: 58.08		TAF3_HUMAN (1-914): 6.23e-88: 302: 100.00
+	Hs
		1056838 BRD3_HUMAN (1-702): 7.67e-145: 442: 100.00		MDC1_HUMAN (6-886): 7.09e-49: 191: 11.56
+	Hs
		1067107 BRD3_HUMAN (1-702): 7.67e-145: 442: 100.00		RSF1_HUMAN (161-915): 1.32e-37: 155: 10.46
+	Hs
		631425 BRD2_HUMAN (5-700): 1.46e-129: 405: 58.08		MDC1_HUMAN (6-886): 7.09e-49: 191: 11.56
+	Hs
		1067096 BRD3_HUMAN (1-702): 7.67e-145: 442: 100.00		CHAP1_HUMAN (118-739): 9.43e-30: 128: 11.47
+	Hs
		631557 BRD2_HUMAN (5-700): 1.46e-129: 405: 58.08		RSF1_HUMAN (161-915): 1.32e-37: 155: 10.46
+	Hs
		1067006 BRD3_HUMAN (1-702): 7.67e-145: 442: 100.00		NIPBL_HUMAN (274-754): 7.04e-10: 65.4: 16.73
+	Hs
		1067060 BRD3_HUMAN (1-702): 7.67e-145: 442: 100.00		THOC2_HUMAN (339-641): 7.81e-10: 65.4: 20.26
+	Hs
		1139024 KAT2A_HUMAN (267-414): 1.15e-33: 140: 28.86		TAF3_HUMAN (1-914): 6.23e-88: 302: 100.00
+	Hs
		244558 BRD4_HUMAN (273-605): 9.08e-20: 96.8: 17.56		TAF3_HUMAN (1-914): 6.23e-88: 302: 100.00
+	Hs
		244466 BRD4_HUMAN (273-605): 9.08e-20: 96.8: 17.56		PLEC_HUMAN (30-873): 1.38e-72: 265: 10.21
+	Hs
		998710 EP300_HUMAN (4-177): 1.2e-34: 144: 22.86		MDC1_HUMAN (6-886): 7.09e-49: 191: 11.56
+	Hs
		999001 EP300_HUMAN (4-177): 1.2e-34: 144: 22.86		RSF1_HUMAN (161-915): 1.32e-37: 155: 10.46
+	Hs
		244438 BRD4_HUMAN (273-605): 9.08e-20: 96.8: 17.56		MDC1_HUMAN (6-886): 7.09e-49: 191: 11.56
+	Hs
		244826 BRD4_HUMAN (273-605): 9.08e-20: 96.8: 17.56		RSF1_HUMAN (161-915): 1.32e-37: 155: 10.46
+	Hs
		1071482 ZMY11_HUMAN (3-446): 1.03e-44: 171: 9.63		TITIN_HUMAN (187-860): 3.72e-13: 76.3: 9.87
+	Hs
		244791 BRD4_HUMAN (273-605): 9.08e-20: 96.8: 17.56		CHAP1_HUMAN (118-739): 9.43e-30: 128: 11.47
+	Dm
		532749 FSH_DROME (277-481): 4.78e-28: 123: 26.21		Q9VLS7_DROME (89-877): 5.22e-10: 65.9: 8.04
+	Hs
		244571 BRD4_HUMAN (273-605): 9.08e-20: 96.8: 17.56		NIPBL_HUMAN (274-754): 7.04e-10: 65.4: 16.73
+	Hs
		244681 BRD4_HUMAN (273-605): 9.08e-20: 96.8: 17.56		THOC2_HUMAN (339-641): 7.81e-10: 65.4: 20.26