HitPredict

Interactor 1: BRD3 (Q15059)
Bromodomain-containing protein 3 (RING3-like protein)
Gene: BRD3

Interactor 2: REQU (Q92785)
Zinc finger protein ubi-d4 (Apoptosis response zinc finger protein) (BRG1-associated factor 45D) (BAF45D) (D4, zinc and double PHD fingers family 2) (Protein requiem)
Gene: DPF2

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	30554943
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Bromodomain~PHD
Common GO terms	GO:0000785 - chromatin GO:0005634 - nucleus GO:0006338 - chromatin remodeling GO:0006357 - regulation of transcription by RNA polymerase II GO:0070577 - lysine-acetylated histone binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 726 Hs			1 391
+	Hs
		1059625 BRD3_HUMAN (1-702): 7.67e-145: 442: 100.00		CHD4_HUMAN (32-382): 5.17e-44: 165: 12.73
+	Hs
		631414 BRD2_HUMAN (5-700): 1.46e-129: 405: 58.08		CHD3_HUMAN (43-382): 1.44e-49: 181: 13.23
+	Hs
		975255 BRD3_HUMAN (1-702): 7.67e-145: 442: 100.00		KMT2A_HUMAN (80-388): 8.66e-36: 141: 14.38
+	Hs
		1067099 BRD3_HUMAN (1-702): 7.67e-145: 442: 100.00		NSD1_HUMAN (101-375): 8.5e-35: 138: 17.97
+	Hs
		631426 BRD2_HUMAN (5-700): 1.46e-129: 405: 58.08		CHD4_HUMAN (32-382): 5.17e-44: 165: 12.73
+	Hs
		170259 BRD2_HUMAN (5-700): 1.46e-129: 405: 58.08		TIF1A_HUMAN (25-391): 1.7e-32: 131: 14.06
+	Hs
		631520 BRD2_HUMAN (5-700): 1.46e-129: 405: 58.08		PHF10_HUMAN (226-384): 1.03e-31: 127: 35.19
+	Hs
		631624 BRD2_HUMAN (5-700): 1.46e-129: 405: 58.08		BAZ2A_HUMAN (329-375): 3.73e-18: 88.7: 51.06
+	Hs
		998938 EP300_HUMAN (4-177): 1.2e-34: 144: 22.86		DPF3_HUMAN (1-388): 3.83e-99: 301: 61.60
+	Hs
		1018748 ZMYD8_HUMAN (3-725): 8.92e-52: 196: 12.21		CHD3_HUMAN (43-382): 1.44e-49: 181: 13.23
+	Hs
		1059940 ZMYD8_HUMAN (3-725): 8.92e-52: 196: 12.21		CHD4_HUMAN (32-382): 5.17e-44: 165: 12.73
+	Hs
		1255051 ZMYD8_HUMAN (3-725): 8.92e-52: 196: 12.21		CHD5_HUMAN (43-382): 1.39e-42: 161: 14.40
+	Hs
		782398 ZMYD8_HUMAN (3-725): 8.92e-52: 196: 12.21		KDM5C_HUMAN (122-391): 3.54e-38: 148: 21.69
+	Hs
		998619 EP300_HUMAN (4-177): 1.2e-34: 144: 22.86		CHD3_HUMAN (43-382): 1.44e-49: 181: 13.23
+	Mm
		101463 F8VPR5_MOUSE (19-143): 9.58e-32: 135: 30.23		TRI33_MOUSE (6-389): 2.47e-52: 189: 12.69
+	Hs
		975259 ZMY11_HUMAN (3-446): 1.03e-44: 171: 9.63		KMT2A_HUMAN (80-388): 8.66e-36: 141: 14.38
+	Hs
		998717 EP300_HUMAN (4-177): 1.2e-34: 144: 22.86		CHD4_HUMAN (32-382): 5.17e-44: 165: 12.73
+	Mm
		70929 EP300_MOUSE (4-177): 2.63e-34: 143: 22.86		CHD4_MOUSE (32-382): 9.67e-44: 164: 12.73
+	Hs
		998941 EP300_HUMAN (4-177): 1.2e-34: 144: 22.86		KAT6A_HUMAN (76-387): 3.75e-43: 162: 26.48
+	Hs
		666553 ZMYD8_HUMAN (3-725): 8.92e-52: 196: 12.21		KDM5A_HUMAN (309-375): 1.26e-20: 96.4: 35.82