HitPredict

Interactor 1: BRD3 (Q15059)
Bromodomain-containing protein 3 (RING3-like protein)
Gene: BRD3

Interactor 2: M3K5 (Q99683)
Mitogen-activated protein kinase kinase kinase 5 (EC 2.7.11.25) (Apoptosis signal-regulating kinase 1) (ASK-1) (MAPK/ERK kinase kinase 5) (MEK kinase 5) (MEKK 5)
Gene: MAP3K5

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.50	0.437

Property	Details
Experiments	30554943
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	-
Homologous interactions	11

Homologous interactions

Color coding for hit scores

	1 726 Hs			1 1374
+	Hs
		999014 EP300_HUMAN (4-177): 1.2e-34: 144: 22.86		M3K5_HUMAN (1-1374): 0: 1497: 100.00
+	Hs
		254474 EP300_HUMAN (4-177): 1.2e-34: 144: 22.86		ROCK2_HUMAN (668-1343): 7.3e-114: 392: 17.55
+	Mm
		101422 F8VPR5_MOUSE (19-143): 9.58e-32: 135: 30.23		KS6A3_MOUSE (623-1074): 9.86e-118: 387: 19.83
+	Hs
		270406 EP300_HUMAN (4-177): 1.2e-34: 144: 22.86		KS6A5_HUMAN (673-1088): 5.06e-109: 365: 19.51
+	Hs
		998640 EP300_HUMAN (4-177): 1.2e-34: 144: 22.86		PAK2_HUMAN (686-960): 1.26e-97: 325: 31.27
+	Hs
		160280 BRD4_HUMAN (273-605): 9.08e-20: 96.8: 17.56		AURKA_HUMAN (551-947): 1.43e-115: 369: 22.36
+	Hs
		244376 BRD4_HUMAN (273-605): 9.08e-20: 96.8: 17.56		PAK2_HUMAN (686-960): 1.26e-97: 325: 31.27
+	Sc
		964736 BDF2_YEAST (250-500): 3e-24: 110: 20.32		BCK1_YEAST (685-969): 7.75e-43: 173: 38.59
+	Hs
		681812 EP300_HUMAN (4-177): 1.2e-34: 144: 22.86		AKT1_HUMAN (438-615): 7.18e-25: 112: 13.64
+	Hs
		681961 KAT2A_HUMAN (267-414): 1.15e-33: 140: 28.86		AKT1_HUMAN (438-615): 7.18e-25: 112: 13.64
+	Hs
		681962 KAT2B_HUMAN (267-414): 8.8e-32: 134: 25.50		AKT1_HUMAN (438-615): 7.18e-25: 112: 13.64